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Red blood cell distribution width and 1-year mortality in acute heart failure.

Publication ,  Journal Article
van Kimmenade, RRJ; Mohammed, AA; Uthamalingam, S; van der Meer, P; Felker, GM; Januzzi, JL
Published in: Eur J Heart Fail
February 2010

AIMS: Red blood cell distribution width (RDW) predicts mortality in chronic heart failure (HF) and stable coronary artery disease. The prognostic value of RDW in more acute settings such as acute HF, and its relative prognostic value compared with more established measures such as N-terminal pro-brain natriuretic peptide (NT-proBNP), remains unknown. METHODS AND RESULTS: In a cohort of 205 patients with acute HF, independent predictors of RDW were identified using linear regression analysis. The association between RDW and 1-year survival in the context of other predictors was assessed using Cox's proportional hazards analysis. Red blood cell distribution width was elevated in 67 (32.7%) patients; RDW was independently associated with haematological variables such as haemoglobin (P < 0.001) as well as the use of loop diuretics (P = 0.006) and beta-blockers (P = 0.015) on presentation, but not with nutritional deficiencies, recent transfusion, or inflammatory variables. Log-transformed RDW values independently predicted mortality in multivariable Cox's proportional hazards analysis (hazards ratio, 1.03; 95% confidence interval, 1.00-1.06; P = 0.04); when stratified on the basis of RDW and NT-proBNP status, the combination provided additional prognostic information. CONCLUSION: Red blood cell distribution width is frequently elevated among patients with acute HF and does not appear to be associated with nutritional status, transfusion history, or inflammation. Red blood cell distribution width independently predicts 1-year mortality in acute HF. The value of RDW appears additive to other established prognostic variables such as NT-proBNP.

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Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

February 2010

Volume

12

Issue

2

Start / End Page

129 / 136

Location

England

Related Subject Headings

  • Time Factors
  • Sodium Potassium Chloride Symporter Inhibitors
  • Risk Factors
  • Proportional Hazards Models
  • Prognosis
  • Predictive Value of Tests
  • Peptide Fragments
  • Natriuretic Peptide, Brain
  • Multivariate Analysis
  • Massachusetts
 

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van Kimmenade, R. R. J., Mohammed, A. A., Uthamalingam, S., van der Meer, P., Felker, G. M., & Januzzi, J. L. (2010). Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail, 12(2), 129–136. https://doi.org/10.1093/eurjhf/hfp179
Kimmenade, Roland R. J. van, Asim A. Mohammed, Shanmugam Uthamalingam, Peter van der Meer, G Michael Felker, and James L. Januzzi. “Red blood cell distribution width and 1-year mortality in acute heart failure.Eur J Heart Fail 12, no. 2 (February 2010): 129–36. https://doi.org/10.1093/eurjhf/hfp179.
van Kimmenade RRJ, Mohammed AA, Uthamalingam S, van der Meer P, Felker GM, Januzzi JL. Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail. 2010 Feb;12(2):129–36.
van Kimmenade, Roland R. J., et al. “Red blood cell distribution width and 1-year mortality in acute heart failure.Eur J Heart Fail, vol. 12, no. 2, Feb. 2010, pp. 129–36. Pubmed, doi:10.1093/eurjhf/hfp179.
van Kimmenade RRJ, Mohammed AA, Uthamalingam S, van der Meer P, Felker GM, Januzzi JL. Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail. 2010 Feb;12(2):129–136.
Journal cover image

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

February 2010

Volume

12

Issue

2

Start / End Page

129 / 136

Location

England

Related Subject Headings

  • Time Factors
  • Sodium Potassium Chloride Symporter Inhibitors
  • Risk Factors
  • Proportional Hazards Models
  • Prognosis
  • Predictive Value of Tests
  • Peptide Fragments
  • Natriuretic Peptide, Brain
  • Multivariate Analysis
  • Massachusetts