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Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure.

Publication ,  Journal Article
Adams, KF; Piña, IL; Ghali, JK; Wagoner, LE; Dunlap, SH; Schwartz, TA; Stough, WG; Mehra, MR; Felker, GM; Chiong, JR; Patterson, JH; Kim, J ...
Published in: Am Heart J
December 2009

BACKGROUND: Reduced hemoglobin has been associated with adverse outcomes in heart failure, but the relationship of hemoglobin to health-related quality of life in outpatients with this syndrome has not been well studied. METHODS: We used data from the prospective, observational Study of Anemia in a Heart Failure Population Registry, which randomly selected outpatients with heart failure from specialty or community cardiology clinics. Hemoglobin was determined by finger stick at baseline and during medically indicated follow-up visits. Health-related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire and the Minnesota Living with Heart Failure Questionnaire at 3-month intervals for 12 months. RESULTS: Adjusted regression analysis demonstrated a significant, direct, linear relationship between hemoglobin and health-related quality of life from baseline through 12 months follow-up on all Kansas City Cardiomyopathy Questionnaire domains (all P < .001) and the Summary and Physical domains of the Minnesota Living with Heart Failure Questionnaire (all P < .05). Adjusted categorical analysis of the change in Kansas City Cardiomyopathy Questionnaire Clinical scores associated with change in hemoglobin from baseline to 6 months also showed a significant relationship between increasing hemoglobin and improved health status (5.9 +/- 1.8 units for a hemoglobin increase of >or=1 g/dL, 0.7 +/- 1.2 units for change in hemoglobin <1 g/dL, and -2.6 +/- 1.4 units for a >or=1 g/dL decrease in hemoglobin, P < .001). CONCLUSIONS: These prospective, observational results indicate that reduced hemoglobin is associated with poorer quality of life in patients with heart failure. Additional studies will be required to establish if this is a cause-and-effect relationship.

Duke Scholars

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

December 2009

Volume

158

Issue

6

Start / End Page

965 / 971

Location

United States

Related Subject Headings

  • Quality of Life
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Hemoglobins
  • Heart Failure
  • Female
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Adams, K. F., Piña, I. L., Ghali, J. K., Wagoner, L. E., Dunlap, S. H., Schwartz, T. A., … Oren, R. M. (2009). Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure. Am Heart J, 158(6), 965–971. https://doi.org/10.1016/j.ahj.2009.10.015
Adams, Kirkwood F., Ileana L. Piña, Jalal K. Ghali, Lynne E. Wagoner, Stephanie H. Dunlap, Todd A. Schwartz, Wendy Gattis Stough, et al. “Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure.Am Heart J 158, no. 6 (December 2009): 965–71. https://doi.org/10.1016/j.ahj.2009.10.015.
Adams KF, Piña IL, Ghali JK, Wagoner LE, Dunlap SH, Schwartz TA, et al. Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure. Am Heart J. 2009 Dec;158(6):965–71.
Adams, Kirkwood F., et al. “Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure.Am Heart J, vol. 158, no. 6, Dec. 2009, pp. 965–71. Pubmed, doi:10.1016/j.ahj.2009.10.015.
Adams KF, Piña IL, Ghali JK, Wagoner LE, Dunlap SH, Schwartz TA, Stough WG, Mehra MR, Felker GM, Chiong JR, Patterson JH, Kim J, Butler J, Oren RM. Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure. Am Heart J. 2009 Dec;158(6):965–971.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

December 2009

Volume

158

Issue

6

Start / End Page

965 / 971

Location

United States

Related Subject Headings

  • Quality of Life
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Hemoglobins
  • Heart Failure
  • Female
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology