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The immune response during acute HIV-1 infection: clues for vaccine development.

Publication ,  Journal Article
McMichael, AJ; Borrow, P; Tomaras, GD; Goonetilleke, N; Haynes, BF
Published in: Nat Rev Immunol
January 2010

The early immune response to HIV-1 infection is likely to be an important factor in determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies that arise following a mucosal infection are usually derived from a single transmitted virus. Moreover, the finding that the first effective immune responses drive the selection of virus escape mutations provides insight into the earliest immune responses against the transmitted virus and their contributions to the control of acute viraemia. Strong innate and adaptive immune responses occur subsequently but they are too late to eliminate the infection. In this Review, we discuss recent studies on the kinetics and quality of early immune responses to HIV-1 and their implications for developing a successful preventive HIV-1 vaccine.

Duke Scholars

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Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

January 2010

Volume

10

Issue

1

Start / End Page

11 / 23

Location

England

Related Subject Headings

  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Macaca
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Animals
  • AIDS Vaccines
 

Citation

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McMichael, A. J., Borrow, P., Tomaras, G. D., Goonetilleke, N., & Haynes, B. F. (2010). The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol, 10(1), 11–23. https://doi.org/10.1038/nri2674
McMichael, Andrew J., Persephone Borrow, Georgia D. Tomaras, Nilu Goonetilleke, and Barton F. Haynes. “The immune response during acute HIV-1 infection: clues for vaccine development.Nat Rev Immunol 10, no. 1 (January 2010): 11–23. https://doi.org/10.1038/nri2674.
McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF. The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol. 2010 Jan;10(1):11–23.
McMichael, Andrew J., et al. “The immune response during acute HIV-1 infection: clues for vaccine development.Nat Rev Immunol, vol. 10, no. 1, Jan. 2010, pp. 11–23. Pubmed, doi:10.1038/nri2674.
McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF. The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol. 2010 Jan;10(1):11–23.

Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

January 2010

Volume

10

Issue

1

Start / End Page

11 / 23

Location

England

Related Subject Headings

  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Macaca
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Animals
  • AIDS Vaccines