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Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

Publication ,  Journal Article
Haynes, BF; Fleming, J; St Clair, EW; Katinger, H; Stiegler, G; Kunert, R; Robinson, J; Scearce, RM; Plonk, K; Staats, HF; Ortel, TL; Alam, SM ...
Published in: Science
June 24, 2005

The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing antibody responses by using HIV-1 vaccines.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 24, 2005

Volume

308

Issue

5730

Start / End Page

1906 / 1908

Location

United States

Related Subject Headings

  • Neutralization Tests
  • Molecular Mimicry
  • Mice
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp41
  • HIV Antibodies
  • General Science & Technology
  • Epitopes
 

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Haynes, B. F., Fleming, J., St Clair, E. W., Katinger, H., Stiegler, G., Kunert, R., … Alam, S. M. (2005). Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science, 308(5730), 1906–1908. https://doi.org/10.1126/science.1111781
Haynes, Barton F., Judith Fleming, E William St Clair, Herman Katinger, Gabriela Stiegler, Renate Kunert, James Robinson, et al. “Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.Science 308, no. 5730 (June 24, 2005): 1906–8. https://doi.org/10.1126/science.1111781.
Haynes BF, Fleming J, St Clair EW, Katinger H, Stiegler G, Kunert R, et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science. 2005 Jun 24;308(5730):1906–8.
Haynes, Barton F., et al. “Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.Science, vol. 308, no. 5730, June 2005, pp. 1906–08. Pubmed, doi:10.1126/science.1111781.
Haynes BF, Fleming J, St Clair EW, Katinger H, Stiegler G, Kunert R, Robinson J, Scearce RM, Plonk K, Staats HF, Ortel TL, Liao H-X, Alam SM. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science. 2005 Jun 24;308(5730):1906–1908.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 24, 2005

Volume

308

Issue

5730

Start / End Page

1906 / 1908

Location

United States

Related Subject Headings

  • Neutralization Tests
  • Molecular Mimicry
  • Mice
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp41
  • HIV Antibodies
  • General Science & Technology
  • Epitopes