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HIV-1-specific antibody responses during acute and chronic HIV-1 infection.

Publication ,  Journal Article
Tomaras, GD; Haynes, BF
Published in: Curr Opin HIV AIDS
September 2009

PURPOSE OF REVIEW: The humoral immune response to HIV-1 throughout infection is comprised of complex mixtures of antibody isotypes with numerous HIV-1 specificities. However, unlike antibody responses to most infections, protective antibody responses are delayed and do not arise until long after HIV-1 latency is established. We review recent data on HIV-1-specific antibody isotypes induced following HIV-1 transmission: to understand the effects of HIV-1 on B cell and T cell effector responses, to understand the timing of the rise and fall of different anti-HIV-1 antibodies and to understand how antibodies could contribute to protective immunity if they were either pre-existing or elicited immediately after HIV-1 transmission. RECENT FINDINGS: Studies of the earliest events following infection by the transmitted/founder virus have recently revealed that early destruction of B cell generative microenvironments may be responsible for delay of potentially protective anti-HIV-1 antibody responses. Unlike the initial CD8 T cell response to HIV-1, the initial induced antibody response is usually ineffective in controlling virus replication during acute HIV-1 infection. SUMMARY: The antibody isotypes and specificities elicited during HIV-1 infection can provide a window into deciphering the detrimental effects of HIV-1 on B cell and T cell responses. Additionally, further characterization of the virus inhibitory capabilities of anti-HIV-1 antibody isotypes can define the spectrum of potential protective HIV-1 antibodies that could be readily elicited by experimental vaccines and adjuvants.

Duke Scholars

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Published In

Curr Opin HIV AIDS

DOI

EISSN

1746-6318

Publication Date

September 2009

Volume

4

Issue

5

Start / End Page

373 / 379

Location

United States

Related Subject Headings

  • Virology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • 4202 Epidemiology
  • 3207 Medical microbiology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
 

Citation

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Chicago
ICMJE
MLA
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Tomaras, G. D., & Haynes, B. F. (2009). HIV-1-specific antibody responses during acute and chronic HIV-1 infection. Curr Opin HIV AIDS, 4(5), 373–379. https://doi.org/10.1097/COH.0b013e32832f00c0
Tomaras, Georgia D., and Barton F. Haynes. “HIV-1-specific antibody responses during acute and chronic HIV-1 infection.Curr Opin HIV AIDS 4, no. 5 (September 2009): 373–79. https://doi.org/10.1097/COH.0b013e32832f00c0.
Tomaras GD, Haynes BF. HIV-1-specific antibody responses during acute and chronic HIV-1 infection. Curr Opin HIV AIDS. 2009 Sep;4(5):373–9.
Tomaras, Georgia D., and Barton F. Haynes. “HIV-1-specific antibody responses during acute and chronic HIV-1 infection.Curr Opin HIV AIDS, vol. 4, no. 5, Sept. 2009, pp. 373–79. Pubmed, doi:10.1097/COH.0b013e32832f00c0.
Tomaras GD, Haynes BF. HIV-1-specific antibody responses during acute and chronic HIV-1 infection. Curr Opin HIV AIDS. 2009 Sep;4(5):373–379.

Published In

Curr Opin HIV AIDS

DOI

EISSN

1746-6318

Publication Date

September 2009

Volume

4

Issue

5

Start / End Page

373 / 379

Location

United States

Related Subject Headings

  • Virology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • 4202 Epidemiology
  • 3207 Medical microbiology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services