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Immune reconstitution in patients with HIV infection.

Publication ,  Journal Article
Sempowski, GD; Haynes, BF
Published in: Annu Rev Med
2002

The peripheral T cell pool is damaged by HIV-1 infection and can be regenerated by production of new T lymphocytes either from the thymus or from proliferation of post-thymic T cells. A critical question for AIDS patients is whether treatment with antiretroviral drugs can restore the capability to produce new T lymphocytes. The development of a new assay of thymus function in adults (the measurement of T cell receptor excision circles, TRECs), and studies of thymus biopsies in untreated and treated HIV-1-infected patients, have suggested that in select patients the thymus can regenerate on antiretroviral therapy. New strategies to overcome the thymic atrophy of aging are needed to improve thymic function in the majority of AIDS patients.

Duke Scholars

Published In

Annu Rev Med

DOI

ISSN

0066-4219

Publication Date

2002

Volume

53

Start / End Page

269 / 284

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Regeneration
  • Humans
  • HIV Infections
  • General & Internal Medicine
  • Atrophy
  • Anti-HIV Agents
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sempowski, G. D., & Haynes, B. F. (2002). Immune reconstitution in patients with HIV infection. Annu Rev Med, 53, 269–284. https://doi.org/10.1146/annurev.med.53.082901.104032
Sempowski, Gregory D., and Barton F. Haynes. “Immune reconstitution in patients with HIV infection.Annu Rev Med 53 (2002): 269–84. https://doi.org/10.1146/annurev.med.53.082901.104032.
Sempowski GD, Haynes BF. Immune reconstitution in patients with HIV infection. Annu Rev Med. 2002;53:269–84.
Sempowski, Gregory D., and Barton F. Haynes. “Immune reconstitution in patients with HIV infection.Annu Rev Med, vol. 53, 2002, pp. 269–84. Pubmed, doi:10.1146/annurev.med.53.082901.104032.
Sempowski GD, Haynes BF. Immune reconstitution in patients with HIV infection. Annu Rev Med. 2002;53:269–284.

Published In

Annu Rev Med

DOI

ISSN

0066-4219

Publication Date

2002

Volume

53

Start / End Page

269 / 284

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Regeneration
  • Humans
  • HIV Infections
  • General & Internal Medicine
  • Atrophy
  • Anti-HIV Agents
  • 3202 Clinical sciences
  • 1103 Clinical Sciences