Immune reconstitution in patients with HIV infection.
Publication
, Journal Article
Sempowski, GD; Haynes, BF
Published in: Annu Rev Med
2002
The peripheral T cell pool is damaged by HIV-1 infection and can be regenerated by production of new T lymphocytes either from the thymus or from proliferation of post-thymic T cells. A critical question for AIDS patients is whether treatment with antiretroviral drugs can restore the capability to produce new T lymphocytes. The development of a new assay of thymus function in adults (the measurement of T cell receptor excision circles, TRECs), and studies of thymus biopsies in untreated and treated HIV-1-infected patients, have suggested that in select patients the thymus can regenerate on antiretroviral therapy. New strategies to overcome the thymic atrophy of aging are needed to improve thymic function in the majority of AIDS patients.
Duke Scholars
Published In
Annu Rev Med
DOI
ISSN
0066-4219
Publication Date
2002
Volume
53
Start / End Page
269 / 284
Location
United States
Related Subject Headings
- Thymus Gland
- T-Lymphocytes
- Regeneration
- Humans
- HIV Infections
- General & Internal Medicine
- Atrophy
- Anti-HIV Agents
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Sempowski, G. D., & Haynes, B. F. (2002). Immune reconstitution in patients with HIV infection. Annu Rev Med, 53, 269–284. https://doi.org/10.1146/annurev.med.53.082901.104032
Sempowski, Gregory D., and Barton F. Haynes. “Immune reconstitution in patients with HIV infection.” Annu Rev Med 53 (2002): 269–84. https://doi.org/10.1146/annurev.med.53.082901.104032.
Sempowski GD, Haynes BF. Immune reconstitution in patients with HIV infection. Annu Rev Med. 2002;53:269–84.
Sempowski, Gregory D., and Barton F. Haynes. “Immune reconstitution in patients with HIV infection.” Annu Rev Med, vol. 53, 2002, pp. 269–84. Pubmed, doi:10.1146/annurev.med.53.082901.104032.
Sempowski GD, Haynes BF. Immune reconstitution in patients with HIV infection. Annu Rev Med. 2002;53:269–284.
Published In
Annu Rev Med
DOI
ISSN
0066-4219
Publication Date
2002
Volume
53
Start / End Page
269 / 284
Location
United States
Related Subject Headings
- Thymus Gland
- T-Lymphocytes
- Regeneration
- Humans
- HIV Infections
- General & Internal Medicine
- Atrophy
- Anti-HIV Agents
- 3202 Clinical sciences
- 1103 Clinical Sciences