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Critical issues in mucosal immunity for HIV-1 vaccine development.

Publication ,  Journal Article
Haynes, BF; Shattock, RJ
Published in: J Allergy Clin Immunol
July 2008

Development of a safe and effective vaccine for HIV-1 infection is a critical global priority. However, the nature of host-virus interactions that lead to early immunosuppression and CD4 depletion, HIV-1 diversity, and the inability of the immune system to eliminate the latently infected CD4 pool of cells has to date thwarted successful vaccine development. Moreover, both the initial antibody-inducing vaccine (protein envelope gp120) and cell-mediated vaccine (recombinant adenovirus containing HIV-1 genes) strategies have failed in efficacy trials, and the latter cell-mediated vaccine appeared to have caused enhanced HIV-1 acquisition. Thus basic and translational research to understand why current vaccines have failed and elucidation of new mechanisms of virus control at mucosal surfaces is essential for eventual successful development of a preventive HIV-1 vaccine.

Duke Scholars

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Published In

J Allergy Clin Immunol

DOI

EISSN

1097-6825

Publication Date

July 2008

Volume

122

Issue

1

Start / End Page

3 / 9

Location

United States

Related Subject Headings

  • Immunity, Mucosal
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • CD4-Positive T-Lymphocytes
  • Animals
  • Allergy
  • AIDS Vaccines
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Haynes, B. F., & Shattock, R. J. (2008). Critical issues in mucosal immunity for HIV-1 vaccine development. J Allergy Clin Immunol, 122(1), 3–9. https://doi.org/10.1016/j.jaci.2008.03.036
Haynes, Barton F., and Robin J. Shattock. “Critical issues in mucosal immunity for HIV-1 vaccine development.J Allergy Clin Immunol 122, no. 1 (July 2008): 3–9. https://doi.org/10.1016/j.jaci.2008.03.036.
Haynes BF, Shattock RJ. Critical issues in mucosal immunity for HIV-1 vaccine development. J Allergy Clin Immunol. 2008 Jul;122(1):3–9.
Haynes, Barton F., and Robin J. Shattock. “Critical issues in mucosal immunity for HIV-1 vaccine development.J Allergy Clin Immunol, vol. 122, no. 1, July 2008, pp. 3–9. Pubmed, doi:10.1016/j.jaci.2008.03.036.
Haynes BF, Shattock RJ. Critical issues in mucosal immunity for HIV-1 vaccine development. J Allergy Clin Immunol. 2008 Jul;122(1):3–9.
Journal cover image

Published In

J Allergy Clin Immunol

DOI

EISSN

1097-6825

Publication Date

July 2008

Volume

122

Issue

1

Start / End Page

3 / 9

Location

United States

Related Subject Headings

  • Immunity, Mucosal
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • CD4-Positive T-Lymphocytes
  • Animals
  • Allergy
  • AIDS Vaccines
  • 3204 Immunology