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Centralized HIV-1 envelope immunogens and neutralizing antibodies.

Publication ,  Journal Article
Gao, F; Liao, H-X; Hahn, BH; Letvin, NL; Korber, BT; Haynes, BF
Published in: Curr HIV Res
November 2007

Centralized HIV-1 genes (consensus, most recent common ancestor and center of the tree) have recently been explored for induction of broadly reactive immune responses to overcome the extraordinary genetic diversity among HIV-1 strains. Although all of these strategies are based on artificial sequences predicted by computer programs, they retain biological function, and use the CCR5 co-receptor for entry into target cells as transmitted HIV-1 Envs. Results from laboratory animals indicate that centralized immunogens are superior to many wild-type immunogens for inducing cross-subtype T and B cell immune responses. Structural modifications have improved the ability of consensus Envs to elicit antibody responses that neutralize a spectrum of HIV-1 Env pseudoviruses. However, the more difficult to neutralize tier 2 Env pseudoviruses are generally not neutralized well by anti-consensus Env antibodies, indicating the need for further modifications, new formulations, or additional strategies to generate antibodies that neutralize a full spectrum of transmitted HIV-1 strains.

Duke Scholars

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Published In

Curr HIV Res

DOI

EISSN

1873-4251

Publication Date

November 2007

Volume

5

Issue

6

Start / End Page

572 / 577

Location

Netherlands

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Virology
  • Vaccines, Synthetic
  • Receptors, CCR5
  • Humans
  • HIV-1
  • Genes, env
  • Consensus Sequence
  • AIDS Vaccines
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gao, F., Liao, H.-X., Hahn, B. H., Letvin, N. L., Korber, B. T., & Haynes, B. F. (2007). Centralized HIV-1 envelope immunogens and neutralizing antibodies. Curr HIV Res, 5(6), 572–577. https://doi.org/10.2174/157016207782418498
Gao, Feng, Hua-Xin Liao, Beatrice H. Hahn, Norman L. Letvin, Bette T. Korber, and Barton F. Haynes. “Centralized HIV-1 envelope immunogens and neutralizing antibodies.Curr HIV Res 5, no. 6 (November 2007): 572–77. https://doi.org/10.2174/157016207782418498.
Gao F, Liao H-X, Hahn BH, Letvin NL, Korber BT, Haynes BF. Centralized HIV-1 envelope immunogens and neutralizing antibodies. Curr HIV Res. 2007 Nov;5(6):572–7.
Gao, Feng, et al. “Centralized HIV-1 envelope immunogens and neutralizing antibodies.Curr HIV Res, vol. 5, no. 6, Nov. 2007, pp. 572–77. Pubmed, doi:10.2174/157016207782418498.
Gao F, Liao H-X, Hahn BH, Letvin NL, Korber BT, Haynes BF. Centralized HIV-1 envelope immunogens and neutralizing antibodies. Curr HIV Res. 2007 Nov;5(6):572–577.

Published In

Curr HIV Res

DOI

EISSN

1873-4251

Publication Date

November 2007

Volume

5

Issue

6

Start / End Page

572 / 577

Location

Netherlands

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Virology
  • Vaccines, Synthetic
  • Receptors, CCR5
  • Humans
  • HIV-1
  • Genes, env
  • Consensus Sequence
  • AIDS Vaccines
  • 42 Health sciences