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Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity.

Publication ,  Journal Article
Gao, F; Korber, BT; Weaver, E; Liao, H-X; Hahn, BH; Haynes, BF
Published in: Expert Rev Vaccines
August 2004

Genetic variation of HIV-1 represents a major obstacle for AIDS vaccine development. With the amino acid sequence divergence as high as 30% in envelopes between different subtypes among HIV-1 group M viruses, it is unlikely that cross-subtype protection will occur equally well among all subtypes. Computer programs have been used to generate 'centralized' HIV gene sequences: consensus, ancestor or center of the tree. These sequences can decrease the genetic distances between the 'centralized' and wild-type gene immunogens to half of those between any wild-type immuongens to each other. Recent studies demonstrated that an artificial group M consensus env gene is equidistant from any subtype and recombinants. It is biologically functional and preserves antigenicity similar to contemporary Env proteins. Most importantly, the group M consensus Env immunogen can elicit both T- and B-cell responses to wild-type HIV-1 isolates.

Duke Scholars

Published In

Expert Rev Vaccines

DOI

ISSN

1476-0584

Publication Date

August 2004

Volume

3

Issue

4 Suppl

Start / End Page

S161 / S168

Location

England

Related Subject Headings

  • Virology
  • Software
  • Humans
  • HIV-1
  • HIV Antigens
  • Genome, Viral
  • Genetic Variation
  • Epitopes, T-Lymphocyte
  • Epitopes, B-Lymphocyte
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gao, F., Korber, B. T., Weaver, E., Liao, H.-X., Hahn, B. H., & Haynes, B. F. (2004). Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. Expert Rev Vaccines, 3(4 Suppl), S161–S168. https://doi.org/10.1586/14760584.3.4.s161
Gao, Feng, Bette T. Korber, Eric Weaver, Hua-Xin Liao, Beatrice H. Hahn, and Barton F. Haynes. “Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity.Expert Rev Vaccines 3, no. 4 Suppl (August 2004): S161–68. https://doi.org/10.1586/14760584.3.4.s161.
Gao F, Korber BT, Weaver E, Liao H-X, Hahn BH, Haynes BF. Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. Expert Rev Vaccines. 2004 Aug;3(4 Suppl):S161–8.
Gao, Feng, et al. “Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity.Expert Rev Vaccines, vol. 3, no. 4 Suppl, Aug. 2004, pp. S161–68. Pubmed, doi:10.1586/14760584.3.4.s161.
Gao F, Korber BT, Weaver E, Liao H-X, Hahn BH, Haynes BF. Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. Expert Rev Vaccines. 2004 Aug;3(4 Suppl):S161–S168.

Published In

Expert Rev Vaccines

DOI

ISSN

1476-0584

Publication Date

August 2004

Volume

3

Issue

4 Suppl

Start / End Page

S161 / S168

Location

England

Related Subject Headings

  • Virology
  • Software
  • Humans
  • HIV-1
  • HIV Antigens
  • Genome, Viral
  • Genetic Variation
  • Epitopes, T-Lymphocyte
  • Epitopes, B-Lymphocyte
  • Animals