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Copper-mediated amidation of heterocyclic and aromatic C-H bonds.

Publication ,  Journal Article
Wang, Q; Schreiber, SL
Published in: Organic letters
November 2009

A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.

Duke Scholars

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Published In

Organic letters

DOI

EISSN

1523-7052

ISSN

1523-7060

Publication Date

November 2009

Volume

11

Issue

22

Start / End Page

5178 / 5180

Related Subject Headings

  • Stereoisomerism
  • Organometallic Compounds
  • Organic Chemistry
  • Molecular Structure
  • Hydrocarbons, Aromatic
  • Heterocyclic Compounds
  • Copper
  • Amides
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

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Wang, Q., & Schreiber, S. L. (2009). Copper-mediated amidation of heterocyclic and aromatic C-H bonds. Organic Letters, 11(22), 5178–5180. https://doi.org/10.1021/ol902079g
Wang, Qiu, and Stuart L. Schreiber. “Copper-mediated amidation of heterocyclic and aromatic C-H bonds.Organic Letters 11, no. 22 (November 2009): 5178–80. https://doi.org/10.1021/ol902079g.
Wang Q, Schreiber SL. Copper-mediated amidation of heterocyclic and aromatic C-H bonds. Organic letters. 2009 Nov;11(22):5178–80.
Wang, Qiu, and Stuart L. Schreiber. “Copper-mediated amidation of heterocyclic and aromatic C-H bonds.Organic Letters, vol. 11, no. 22, Nov. 2009, pp. 5178–80. Epmc, doi:10.1021/ol902079g.
Wang Q, Schreiber SL. Copper-mediated amidation of heterocyclic and aromatic C-H bonds. Organic letters. 2009 Nov;11(22):5178–5180.
Journal cover image

Published In

Organic letters

DOI

EISSN

1523-7052

ISSN

1523-7060

Publication Date

November 2009

Volume

11

Issue

22

Start / End Page

5178 / 5180

Related Subject Headings

  • Stereoisomerism
  • Organometallic Compounds
  • Organic Chemistry
  • Molecular Structure
  • Hydrocarbons, Aromatic
  • Heterocyclic Compounds
  • Copper
  • Amides
  • 34 Chemical sciences
  • 03 Chemical Sciences