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QT as a safety biomarker in drug development.

Publication ,  Journal Article
Whellan, DJ; Green, CL; Piccini, JP; Krucoff, MW
Published in: Clin Pharmacol Ther
July 2009

The cardiovascular safety of new drugs is an overarching concern for all stakeholders: the pharmaceutical industry and the US Food and Drug Administration (FDA) prior to approval and doctors and patients during postrelease drug use. Of the many cardiac safety concerns that accompany development of new drugs--including those related to vasculature and valvular tissue, the potential for myopathies, and the possibility of other electrophysiologic perturbations--the most pressing concern is the potential for ventricular arrhythmias causing sudden death.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

July 2009

Volume

86

Issue

1

Start / End Page

101 / 104

Location

United States

Related Subject Headings

  • Young Adult
  • Pharmacology & Pharmacy
  • Male
  • Long QT Syndrome
  • Humans
  • Female
  • Drugs, Investigational
  • Drug Discovery
  • Biomarkers
  • Aged
 

Citation

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MLA
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Whellan, D. J., Green, C. L., Piccini, J. P., & Krucoff, M. W. (2009). QT as a safety biomarker in drug development. Clin Pharmacol Ther, 86(1), 101–104. https://doi.org/10.1038/clpt.2009.70
Whellan, D. J., C. L. Green, J. P. Piccini, and M. W. Krucoff. “QT as a safety biomarker in drug development.Clin Pharmacol Ther 86, no. 1 (July 2009): 101–4. https://doi.org/10.1038/clpt.2009.70.
Whellan DJ, Green CL, Piccini JP, Krucoff MW. QT as a safety biomarker in drug development. Clin Pharmacol Ther. 2009 Jul;86(1):101–4.
Whellan, D. J., et al. “QT as a safety biomarker in drug development.Clin Pharmacol Ther, vol. 86, no. 1, July 2009, pp. 101–04. Pubmed, doi:10.1038/clpt.2009.70.
Whellan DJ, Green CL, Piccini JP, Krucoff MW. QT as a safety biomarker in drug development. Clin Pharmacol Ther. 2009 Jul;86(1):101–104.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

July 2009

Volume

86

Issue

1

Start / End Page

101 / 104

Location

United States

Related Subject Headings

  • Young Adult
  • Pharmacology & Pharmacy
  • Male
  • Long QT Syndrome
  • Humans
  • Female
  • Drugs, Investigational
  • Drug Discovery
  • Biomarkers
  • Aged