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Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.

Publication ,  Journal Article
Patkar, AA; Mannelli, P; Peindl, K; Hill, KP; Wu, L-T; Lee, T; Kuhn, C
Published in: J Psychiatr Res
October 2008

BACKGROUND: Preclinical evidence indicates that exposure to cocaine influences the activity of the serotonin transporter (5-HTT) as well as several 5-HT receptor subtypes. However, little is known about the relationship between the 5-HTT and 5-HT receptors following cocaine exposure in humans. OBJECTIVE: We examined the relationship between platelet 5-HTT, a presynaptic 5-HT measure, and prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP), a postsynaptic 5-HT receptor agonist in cocaine dependent individuals. METHODS: Platelet [3H] paroxetine binding sites were assayed and the m-CPP challenge test was performed in 35 African American cocaine dependent individuals and 33 controls. Clinical measures included assessments of drug use severity and depression. RESULTS: Cocaine subjects showed reduced Bmax of [3H] paroxetine (t=4.67, p<0.01) and blunted PRL response to m-CPP (F=21.86, p<0.01) compared to controls. There was a positive correlation between Bmax and delta PRL [peak-baseline PRL] in cocaine subjects (r=0.50, p<0.01) but not in controls (r=0.19). ANCOVA analyses showed that the cocaine subgroup with moderate and severe reduction in Bmax showed a greater blunting in PRL response compared to the subgroup with mild Bmax reductions (F=9.44, p<.005). Multivariate regression models showed that the main effects as well as the interaction of Bmax and severity of cocaine use significantly contributed to impaired PRL response (F=17.90, p<.001). CONCLUSIONS: Disturbances in serotonin transporter binding and post-synaptic 5-HT receptor function seem to be associated in cocaine-dependent subjects. Severity of cocaine use appears to mediate this relationship. Whether there is a causal association between the two measures, or cocaine has separate and independent pre- and post-synaptic effects needs to be clarified.

Duke Scholars

Published In

J Psychiatr Res

DOI

ISSN

0022-3956

Publication Date

October 2008

Volume

42

Issue

14

Start / End Page

1213 / 1219

Location

England

Related Subject Headings

  • Tritium
  • Severity of Illness Index
  • Serotonin Receptor Agonists
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Regression Analysis
  • Radioligand Assay
  • Radioimmunoassay
  • Psychiatry
  • Prolactin
 

Citation

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Patkar, A. A., Mannelli, P., Peindl, K., Hill, K. P., Wu, L.-T., Lee, T., & Kuhn, C. (2008). Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence. J Psychiatr Res, 42(14), 1213–1219. https://doi.org/10.1016/j.jpsychires.2008.01.008
Patkar, Ashwin A., Paolo Mannelli, Kathleen Peindl, Kevin P. Hill, Li-Tzy Wu, Tong Lee, and Cynthia Kuhn. “Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.J Psychiatr Res 42, no. 14 (October 2008): 1213–19. https://doi.org/10.1016/j.jpsychires.2008.01.008.
Patkar AA, Mannelli P, Peindl K, Hill KP, Wu L-T, Lee T, et al. Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence. J Psychiatr Res. 2008 Oct;42(14):1213–9.
Patkar, Ashwin A., et al. “Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.J Psychiatr Res, vol. 42, no. 14, Oct. 2008, pp. 1213–19. Pubmed, doi:10.1016/j.jpsychires.2008.01.008.
Patkar AA, Mannelli P, Peindl K, Hill KP, Wu L-T, Lee T, Kuhn C. Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence. J Psychiatr Res. 2008 Oct;42(14):1213–1219.
Journal cover image

Published In

J Psychiatr Res

DOI

ISSN

0022-3956

Publication Date

October 2008

Volume

42

Issue

14

Start / End Page

1213 / 1219

Location

England

Related Subject Headings

  • Tritium
  • Severity of Illness Index
  • Serotonin Receptor Agonists
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Regression Analysis
  • Radioligand Assay
  • Radioimmunoassay
  • Psychiatry
  • Prolactin