Immunoglobulin class switch recombination in chronic lymphocytic leukemia.
Publication
, Journal Article
Lanasa, MC; Weinberg, JB
Published in: Leuk Lymphoma
July 2011
During B lymphocyte maturation, a subset of B cells undergo class switch recombination (CSR), a process wherein the heavy chain constant region is changed to a different immunoglobulin isotype without introduction of variable region mutations. CSR thus allows for the production of various antibody isotypes with different effector functions. Similar to naive B cells, chronic lymphocytic leukemia (CLL) cells co-express surface immunoglobulin (Ig) M and D (IgM+IgD+), though a minority of cases express terminally differentiated isotypes. In this brief report, we discuss the capacity of CLL to undergo CSR and the relevance of CSR to the clinical behavior of CLL.
Duke Scholars
Published In
Leuk Lymphoma
DOI
EISSN
1029-2403
Publication Date
July 2011
Volume
52
Issue
7
Start / End Page
1398 / 1400
Location
United States
Related Subject Headings
- Somatic Hypermutation, Immunoglobulin
- Receptors, Antigen, B-Cell
- Leukemia, Lymphocytic, Chronic, B-Cell
- Immunology
- Immunoglobulin Class Switching
- Humans
- Gene Rearrangement, B-Lymphocyte
- Gene Expression Regulation, Leukemic
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lanasa, M. C., & Weinberg, J. B. (2011). Immunoglobulin class switch recombination in chronic lymphocytic leukemia. Leuk Lymphoma, 52(7), 1398–1400. https://doi.org/10.3109/10428194.2011.568076
Lanasa, Mark C., and J Brice Weinberg. “Immunoglobulin class switch recombination in chronic lymphocytic leukemia.” Leuk Lymphoma 52, no. 7 (July 2011): 1398–1400. https://doi.org/10.3109/10428194.2011.568076.
Lanasa MC, Weinberg JB. Immunoglobulin class switch recombination in chronic lymphocytic leukemia. Leuk Lymphoma. 2011 Jul;52(7):1398–400.
Lanasa, Mark C., and J. Brice Weinberg. “Immunoglobulin class switch recombination in chronic lymphocytic leukemia.” Leuk Lymphoma, vol. 52, no. 7, July 2011, pp. 1398–400. Pubmed, doi:10.3109/10428194.2011.568076.
Lanasa MC, Weinberg JB. Immunoglobulin class switch recombination in chronic lymphocytic leukemia. Leuk Lymphoma. 2011 Jul;52(7):1398–1400.
Published In
Leuk Lymphoma
DOI
EISSN
1029-2403
Publication Date
July 2011
Volume
52
Issue
7
Start / End Page
1398 / 1400
Location
United States
Related Subject Headings
- Somatic Hypermutation, Immunoglobulin
- Receptors, Antigen, B-Cell
- Leukemia, Lymphocytic, Chronic, B-Cell
- Immunology
- Immunoglobulin Class Switching
- Humans
- Gene Rearrangement, B-Lymphocyte
- Gene Expression Regulation, Leukemic
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences