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Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype.

Publication ,  Journal Article
Ahearn, EP; Speer, MC; Chen, YT; Steffens, DC; Cassidy, F; Van Meter, S; Provenzale, JM; Weisler, RH; Krishnan, KRR
Published in: Am J Med Genet
August 8, 2002

The purpose of the study was to consider MRI hyperintensities as a potential endophenotype for bipolar disorder (BPD) and to investigate Notch3 (CADASIL) as a candidate gene for BPD. MRI scans were performed on 21 members of a family with a high incidence of BPD. Two-point and multipoint linkage analyses were performed and two exons of Notch3 were investigated with SSCP. Fifteen of 21 family members had MRI hyperintensities, including all bipolar patients and six family members with no affective illness. Two-point linkage analysis yielded negative results for all models. Multipoint linkage analysis yielded negative results except for Model 1a, in which a maximal LOD score was -1.24. A mutation screen of Exons 3 and 4 was negative. Notch3 does not appear to be a candidate gene for BPD in this family.

Duke Scholars

Published In

Am J Med Genet

DOI

ISSN

0148-7299

Publication Date

August 8, 2002

Volume

114

Issue

6

Start / End Page

652 / 658

Location

United States

Related Subject Headings

  • Receptors, Notch
  • Receptors, Cell Surface
  • Receptor, Notch3
  • Proto-Oncogene Proteins
  • Polymorphism, Single-Stranded Conformational
  • Pedigree
  • Models, Genetic
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ahearn, E. P., Speer, M. C., Chen, Y. T., Steffens, D. C., Cassidy, F., Van Meter, S., … Krishnan, K. R. R. (2002). Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. Am J Med Genet, 114(6), 652–658. https://doi.org/10.1002/ajmg.10512
Ahearn, Eileen P., Marcy C. Speer, Y. T. Chen, David C. Steffens, Frederick Cassidy, Susan Van Meter, James M. Provenzale, Richard H. Weisler, and K Ranga Rama Krishnan. “Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype.Am J Med Genet 114, no. 6 (August 8, 2002): 652–58. https://doi.org/10.1002/ajmg.10512.
Ahearn EP, Speer MC, Chen YT, Steffens DC, Cassidy F, Van Meter S, et al. Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. Am J Med Genet. 2002 Aug 8;114(6):652–8.
Ahearn, Eileen P., et al. “Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype.Am J Med Genet, vol. 114, no. 6, Aug. 2002, pp. 652–58. Pubmed, doi:10.1002/ajmg.10512.
Ahearn EP, Speer MC, Chen YT, Steffens DC, Cassidy F, Van Meter S, Provenzale JM, Weisler RH, Krishnan KRR. Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. Am J Med Genet. 2002 Aug 8;114(6):652–658.

Published In

Am J Med Genet

DOI

ISSN

0148-7299

Publication Date

August 8, 2002

Volume

114

Issue

6

Start / End Page

652 / 658

Location

United States

Related Subject Headings

  • Receptors, Notch
  • Receptors, Cell Surface
  • Receptor, Notch3
  • Proto-Oncogene Proteins
  • Polymorphism, Single-Stranded Conformational
  • Pedigree
  • Models, Genetic
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging