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Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain.

Publication ,  Journal Article
Provenzale, JM; Isaacson, J; Chen, S; Stinnett, S; Liu, C
Published in: AJR Am J Roentgenol
December 2010

OBJECTIVE: The purpose of our study was to correlate decrease in apparent diffusion coefficient (ADC) and increase in fractional anisotropy (FA) in various white matter (WM) regions using diffusion tenor imaging (DTI) within the first year of life. MATERIALS AND METHODS: We performed DTI on 53 infants and measured FA and ADC within 10 WM regions important in brain development. For each region, we calculated the slope of ADC as a function of FA, the correlation coefficient (r) and correlation of determination (r(2)). We performed a group analysis of r values and r(2)values for six WM regions primarily composed of crossing fibers and four regions primarily having parallel fibers. Upon finding that a strong correlation of FA with age existed, we adjusted for age and calculated partial correlation coefficients. RESULTS: Slopes of FA versus ADC ranged from -1.00711 to -1.67592 (p < 0.05); r values ranged from -0.81 to -0.50 and r(2) values from 0.25 to 0.66. The four greatest r(2) values were within WM regions having large numbers of crossing fibers and the three lowest r(2) values were in regions having predominantly parallel fibers. After adjusting for age, slopes ranged from -1.08095 to 0.09612 (p < 0.05 in five cases); partial correlation coefficients ranged from -0.49 to 0.03 and r(2) values from 0.31 to 0.79. The highest partial correlation coefficients were then relatively equally distributed between the two types of WM regions. CONCLUSION: In various regions, FA and ADC evolved with differing degrees of correlation. We found a strong influence of age on the relationship between FA and ADC.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

December 2010

Volume

195

Issue

6

Start / End Page

W456 / W462

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Infant, Newborn
  • Infant
  • Image Processing, Computer-Assisted
  • Humans
  • Diffusion Magnetic Resonance Imaging
  • Brain
  • Anisotropy
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Provenzale, J. M., Isaacson, J., Chen, S., Stinnett, S., & Liu, C. (2010). Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain. AJR Am J Roentgenol, 195(6), W456–W462. https://doi.org/10.2214/AJR.10.4886
Provenzale, James M., Jared Isaacson, Steven Chen, Sandra Stinnett, and Chunlei Liu. “Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain.AJR Am J Roentgenol 195, no. 6 (December 2010): W456–62. https://doi.org/10.2214/AJR.10.4886.
Provenzale JM, Isaacson J, Chen S, Stinnett S, Liu C. Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain. AJR Am J Roentgenol. 2010 Dec;195(6):W456–62.
Provenzale, James M., et al. “Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain.AJR Am J Roentgenol, vol. 195, no. 6, Dec. 2010, pp. W456–62. Pubmed, doi:10.2214/AJR.10.4886.
Provenzale JM, Isaacson J, Chen S, Stinnett S, Liu C. Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain. AJR Am J Roentgenol. 2010 Dec;195(6):W456–W462.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

December 2010

Volume

195

Issue

6

Start / End Page

W456 / W462

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Infant, Newborn
  • Infant
  • Image Processing, Computer-Assisted
  • Humans
  • Diffusion Magnetic Resonance Imaging
  • Brain
  • Anisotropy
  • 3202 Clinical sciences
  • 1103 Clinical Sciences