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Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis.

Publication ,  Journal Article
Hazinski, MF; Iberti, TJ; MacIntyre, NR; Parker, MM; Tribett, D; Prion, S; Chmel, H
Published in: Am J Crit Care
May 1993

OBJECTIVE: To review the epidemiology and pathophysiology of gram-negative sepsis and the new consensus terminology describing the clinical signs of sepsis. DATA SOURCES: Review of the medical literature and compiled data from animal and clinical trials. PARTICIPANTS: Members of the Society of Critical Care Medicine, American College of Chest Physicians and American Association of Critical-Care Nurses with expertise on the subject of sepsis and its complications. RESULTS: Preconference and general sessions were offered at the National Teaching Institutes of the American Association of Critical-Care Nurses, with the goal of clarifying the epidemiology, risk factors and pathophysiology of gram-negative sepsis. In addition, current terminology and new (1992) consensus terminology describing the clinical signs of sepsis were presented. Special emphasis was placed on the role of the healthcare provider in the prevention and recognition of sepsis and the role of the septic mediators in the septic cascade. CONCLUSIONS: If the incidence of sepsis is to be reduced, the healthcare provider must be aware of the risk factors for sepsis and methods of reducing nosocomial infections. A thorough understanding of the role of mediators and consensus terminology used to describe sepsis, severe sepsis, septic shock and multiple organ dysfunction syndrome is necessary to recognize early or progressive signs of sepsis and to initiate state-of-the-art therapy.

Duke Scholars

Published In

Am J Crit Care

ISSN

1062-3264

Publication Date

May 1993

Volume

2

Issue

3

Start / End Page

224 / 235

Location

United States

Related Subject Headings

  • United States
  • Tumor Necrosis Factor-alpha
  • Terminology as Topic
  • Societies, Nursing
  • Societies, Medical
  • Shock, Septic
  • Risk Factors
  • Nursing
  • Nitric Oxide
  • Multiple Organ Failure
 

Citation

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Hazinski, M. F., Iberti, T. J., MacIntyre, N. R., Parker, M. M., Tribett, D., Prion, S., & Chmel, H. (1993). Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis. Am J Crit Care, 2(3), 224–235.
Hazinski, M. F., T. J. Iberti, N. R. MacIntyre, M. M. Parker, D. Tribett, S. Prion, and H. Chmel. “Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis.Am J Crit Care 2, no. 3 (May 1993): 224–35.
Hazinski MF, Iberti TJ, MacIntyre NR, Parker MM, Tribett D, Prion S, et al. Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis. Am J Crit Care. 1993 May;2(3):224–35.
Hazinski, M. F., et al. “Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis.Am J Crit Care, vol. 2, no. 3, May 1993, pp. 224–35.
Hazinski MF, Iberti TJ, MacIntyre NR, Parker MM, Tribett D, Prion S, Chmel H. Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis. Am J Crit Care. 1993 May;2(3):224–235.

Published In

Am J Crit Care

ISSN

1062-3264

Publication Date

May 1993

Volume

2

Issue

3

Start / End Page

224 / 235

Location

United States

Related Subject Headings

  • United States
  • Tumor Necrosis Factor-alpha
  • Terminology as Topic
  • Societies, Nursing
  • Societies, Medical
  • Shock, Septic
  • Risk Factors
  • Nursing
  • Nitric Oxide
  • Multiple Organ Failure