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Water intoxication in a patient with the Prader-Willi syndrome treated with desmopressin for nocturnal enuresis.

Publication ,  Journal Article
Robson, WL; Shashi, V; Nagaraj, S; Nørgaard, JP
Published in: J Urol
February 1997

PURPOSE: We report on a girl with the Prader-Willi syndrome who received desmopressin for nocturnal enuresis, and water intoxication developed after she ingested a large amount of fluid. MATERIALS AND METHODS: The patient received 10 mg. desmopressin at bedtime for enuresis. She was hospitalized when a major motor seizure and coma (Glasgow coma scale 8) occurred after ingesting 48 ounces of fluid. Treatment included 3% saline, followed by 5% dextrose in water and sodium chloride given intravenously. RESULTS: Serum sodium increased to 128 mEq./l. and serum glucose remained normal. Computerized tomography and magnetic resonance imaging of the head were normal and revealed no evidence of cerebral pontine myelinosis. Patient consciousness returned to normal by day 5 after the seizure. CONCLUSIONS: In patients treated with desmopressin the risk of a seizure or altered level of consciousness can be minimized by not ingesting large quantities of fluid. We recommend that patients drink no more than 8 ounces of fluid on any evening that desmopressin is administered.

Duke Scholars

Published In

J Urol

ISSN

0022-5347

Publication Date

February 1997

Volume

157

Issue

2

Start / End Page

646 / 647

Location

United States

Related Subject Headings

  • Water Intoxication
  • Urology & Nephrology
  • Renal Agents
  • Prader-Willi Syndrome
  • Humans
  • Female
  • Enuresis
  • Deamino Arginine Vasopressin
  • Adolescent
  • 1103 Clinical Sciences
 

Citation

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Robson, W. L., Shashi, V., Nagaraj, S., & Nørgaard, J. P. (1997). Water intoxication in a patient with the Prader-Willi syndrome treated with desmopressin for nocturnal enuresis. J Urol, 157(2), 646–647.
Robson, W. L., V. Shashi, S. Nagaraj, and J. P. Nørgaard. “Water intoxication in a patient with the Prader-Willi syndrome treated with desmopressin for nocturnal enuresis.J Urol 157, no. 2 (February 1997): 646–47.
Robson WL, Shashi V, Nagaraj S, Nørgaard JP. Water intoxication in a patient with the Prader-Willi syndrome treated with desmopressin for nocturnal enuresis. J Urol. 1997 Feb;157(2):646–7.
Robson, W. L., et al. “Water intoxication in a patient with the Prader-Willi syndrome treated with desmopressin for nocturnal enuresis.J Urol, vol. 157, no. 2, Feb. 1997, pp. 646–47.
Robson WL, Shashi V, Nagaraj S, Nørgaard JP. Water intoxication in a patient with the Prader-Willi syndrome treated with desmopressin for nocturnal enuresis. J Urol. 1997 Feb;157(2):646–647.
Journal cover image

Published In

J Urol

ISSN

0022-5347

Publication Date

February 1997

Volume

157

Issue

2

Start / End Page

646 / 647

Location

United States

Related Subject Headings

  • Water Intoxication
  • Urology & Nephrology
  • Renal Agents
  • Prader-Willi Syndrome
  • Humans
  • Female
  • Enuresis
  • Deamino Arginine Vasopressin
  • Adolescent
  • 1103 Clinical Sciences