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Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice.

Publication ,  Journal Article
Schramm-Sapyta, NL; Pratt, AR; Winder, DG
Published in: Psychopharmacology
April 2004

Age of initial exposure to addictive substances is inversely proportional to risk of developing drug dependence. There is debate, however, as to whether intake at a young age causes dependency or whether young people who experiment with addictive substances are predisposed to dependency by other factors. OBJECTIVES. We tested the relationship between cocaine exposure at two different ages in mice and the development of subsequent drug-seeking behavior to test for age-specific exposure effects.We performed dose-response analysis of cocaine conditioned place preference (CPP) and locomotor activity in periadolescent and adult C57Bl/6J mice. In addition, we pretreated periadolescent and adult C57Bl/6J mice with cocaine or saline in the home cage or a drug-associated context, and then examined their behavior in a biased CPP procedure in adulthood.Dose-response relationships were similar between the two age groups. In the pretreatment experiments, we observed locomotor sensitization during the pretreatment in periadolescent but not adult mice. We also observed an enhanced aversion to the non-preferred side of the chamber in periadolescent mice compared to adult mice, which was alleviated by cocaine association with that side. Third, we observed that after further conditioning in adulthood, there were no pretreatment-specific effects.Our results are consistent with a "vulnerable brain" hypothesis for responses to cocaine based on our findings that periadolescent mice exhibit greater locomotor sensitization to cocaine, and greater baseline anxiety responses that are alleviated by cocaine exposure compared to adult mice.

Duke Scholars

Published In

Psychopharmacology

DOI

EISSN

1432-2072

ISSN

0033-3158

Publication Date

April 2004

Volume

173

Issue

1-2

Start / End Page

41 / 48

Related Subject Headings

  • Time Factors
  • Reproducibility of Results
  • Psychiatry
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Exploratory Behavior
  • Dose-Response Relationship, Drug
  • Dopamine Uptake Inhibitors
 

Citation

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Schramm-Sapyta, N. L., Pratt, A. R., & Winder, D. G. (2004). Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. Psychopharmacology, 173(1–2), 41–48. https://doi.org/10.1007/s00213-003-1696-3
Schramm-Sapyta, Nicole L., Adeola R. Pratt, and Danny G. Winder. “Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice.Psychopharmacology 173, no. 1–2 (April 2004): 41–48. https://doi.org/10.1007/s00213-003-1696-3.
Schramm-Sapyta NL, Pratt AR, Winder DG. Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. Psychopharmacology. 2004 Apr;173(1–2):41–8.
Schramm-Sapyta, Nicole L., et al. “Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice.Psychopharmacology, vol. 173, no. 1–2, Apr. 2004, pp. 41–48. Epmc, doi:10.1007/s00213-003-1696-3.
Schramm-Sapyta NL, Pratt AR, Winder DG. Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. Psychopharmacology. 2004 Apr;173(1–2):41–48.
Journal cover image

Published In

Psychopharmacology

DOI

EISSN

1432-2072

ISSN

0033-3158

Publication Date

April 2004

Volume

173

Issue

1-2

Start / End Page

41 / 48

Related Subject Headings

  • Time Factors
  • Reproducibility of Results
  • Psychiatry
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Exploratory Behavior
  • Dose-Response Relationship, Drug
  • Dopamine Uptake Inhibitors