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Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers.

Publication ,  Journal Article
Sun, B; Halmos, G; Schally, AV; Wang, X; Martinez, M
Published in: Prostate
March 1, 2000

BACKGROUND: Bombesin-like peptides can function as autocrine or paracrine growth factors and stimulate the growth of some cancer cells, including human prostate cancer. Three bombesin receptor subtypes, termed gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMBR), and bombesin receptor subtype 3 (BRS-3), have been identified in rodents and humans. METHODS: We investigated the presence and characteristics of the functional receptors for bombesin/GRP in human prostate adenocarcinoma specimens by radio-receptor assay and the mRNA expression of the three bombesin receptor subtypes by RT-PCR. RESULTS: Of the 80 specimens of primary prostate cancer examined by receptor binding assays, 50 ( approximately 63%) showed high-affinity, low-capacity binding sites for bombesin/GRP, and 12 of these 50 receptor-positive specimens also showed a second binding site. Of the 22 prostate cancer specimens analyzed by RT-PCR, 20 (91%) expressed GRPR mRNA, 3 (14%) showed NMBR mRNA, and 2 ( approximately 9%) revealed BRS-3 mRNA. No correlation was observed between receptor expression and patients' age or pathological data. CONCLUSIONS: The detection of a wide distribution of bombesin/GRP receptors in human prostate carcinomas supports the view that they may be involved in modulation of tumor progression and suggests that approaches based on binding of bombesin receptor antagonists or new targeted cytotoxic bombesin analogs to prostate cancers could be considered for the therapy.

Duke Scholars

Published In

Prostate

DOI

ISSN

0270-4137

Publication Date

March 1, 2000

Volume

42

Issue

4

Start / End Page

295 / 303

Location

United States

Related Subject Headings

  • Reverse Transcriptase Polymerase Chain Reaction
  • Receptors, Bombesin
  • Radioligand Assay
  • RNA, Messenger
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Gene Expression
 

Citation

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Sun, B., Halmos, G., Schally, A. V., Wang, X., & Martinez, M. (2000). Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers. Prostate, 42(4), 295–303. https://doi.org/10.1002/(sici)1097-0045(20000301)42:4<295::aid-pros7>3.0.co;2-b
Sun, B., G. Halmos, A. V. Schally, X. Wang, and M. Martinez. “Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers.Prostate 42, no. 4 (March 1, 2000): 295–303. https://doi.org/10.1002/(sici)1097-0045(20000301)42:4<295::aid-pros7>3.0.co;2-b.
Sun B, Halmos G, Schally AV, Wang X, Martinez M. Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers. Prostate. 2000 Mar 1;42(4):295–303.
Sun, B., et al. “Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers.Prostate, vol. 42, no. 4, Mar. 2000, pp. 295–303. Pubmed, doi:10.1002/(sici)1097-0045(20000301)42:4<295::aid-pros7>3.0.co;2-b.
Sun B, Halmos G, Schally AV, Wang X, Martinez M. Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancers. Prostate. 2000 Mar 1;42(4):295–303.
Journal cover image

Published In

Prostate

DOI

ISSN

0270-4137

Publication Date

March 1, 2000

Volume

42

Issue

4

Start / End Page

295 / 303

Location

United States

Related Subject Headings

  • Reverse Transcriptase Polymerase Chain Reaction
  • Receptors, Bombesin
  • Radioligand Assay
  • RNA, Messenger
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Gene Expression