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Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection.

Publication ,  Journal Article
Permar, SR; Kang, HH; Carville, A; Wilks, AB; Mansfield, KG; Rao, SS; Letvin, NL
Published in: J Infect Dis
January 15, 2010

Acute human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) infection is associated with a massive depletion of memory CD4(+) T lymphocytes in the gastrointestinal tract. To define the dynamics of the CD4(+) T lymphocyte subpopulations in breast milk during acute HIV or SIV infection, lymphocyte populations were monitored in blood and milk of 4 Mamu-A*01(+) rhesus monkeys after SIVmac251 inoculation. Strikingly, although the CD4(+) T lymphocytes in blood were depleted during the peak of viremia, the milk CD4(+) T lymphocyte counts remained unchanged, despite active virus replication in the breast milk compartment. Moreover, CD4(+) memory T lymphocytes were preserved in breast milk during acute infection. CD4(+) T lymphocytes in breast milk and other mucosal compartments of uninfected monkeys were similar in their memory phenotype, activation status, and chemokine (C-C motif) receptor 5 expression. Interestingly, the number and proportion of effector CD8(+) T lymphocytes in milk were increased during acute SIV infection, suggesting effective control of virus-mediated CD4(+) T lymphocyte destruction in the breast milk compartment.

Duke Scholars

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

January 15, 2010

Volume

201

Issue

2

Start / End Page

302 / 310

Location

United States

Related Subject Headings

  • Viremia
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Milk, Human
  • Microbiology
  • Macaca mulatta
  • Flow Cytometry
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Permar, S. R., Kang, H. H., Carville, A., Wilks, A. B., Mansfield, K. G., Rao, S. S., & Letvin, N. L. (2010). Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection. J Infect Dis, 201(2), 302–310. https://doi.org/10.1086/649229
Permar, Sallie R., Helen H. Kang, Angela Carville, Andrew B. Wilks, Keith G. Mansfield, Srinivas S. Rao, and Norman L. Letvin. “Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection.J Infect Dis 201, no. 2 (January 15, 2010): 302–10. https://doi.org/10.1086/649229.
Permar SR, Kang HH, Carville A, Wilks AB, Mansfield KG, Rao SS, et al. Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection. J Infect Dis. 2010 Jan 15;201(2):302–10.
Permar, Sallie R., et al. “Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection.J Infect Dis, vol. 201, no. 2, Jan. 2010, pp. 302–10. Pubmed, doi:10.1086/649229.
Permar SR, Kang HH, Carville A, Wilks AB, Mansfield KG, Rao SS, Letvin NL. Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection. J Infect Dis. 2010 Jan 15;201(2):302–310.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

January 15, 2010

Volume

201

Issue

2

Start / End Page

302 / 310

Location

United States

Related Subject Headings

  • Viremia
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Milk, Human
  • Microbiology
  • Macaca mulatta
  • Flow Cytometry
  • Female