A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
Publication
, Journal Article
Yoon, W; Ma, B-J; Fellay, J; Huang, W; Xia, S-M; Zhang, R; Shianna, KV; Liao, H-X; Haynes, BF; Goldstein, DB ...
Published in: AIDS
January 2, 2010
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.
Duke Scholars
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
January 2, 2010
Volume
24
Issue
1
Start / End Page
155 / 157
Location
England
Related Subject Headings
- Virology
- Viral Load
- RNA, Untranslated
- RNA, Long Noncoding
- Polymorphism, Single Nucleotide
- Major Histocompatibility Complex
- Humans
- HLA-B Antigens
- HIV-1
- HIV Infections
Citation
APA
Chicago
ICMJE
MLA
NLM
Yoon, W., Ma, B.-J., Fellay, J., Huang, W., Xia, S.-M., Zhang, R., … NIAID Center for HIV/AIDS Vaccine Immunology, . (2010). A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro. AIDS, 24(1), 155–157. https://doi.org/10.1097/QAD.0b013e32833202f5
Yoon, Woohyun, Ben-Jiang Ma, Jacques Fellay, Wei Huang, Shi-Mao Xia, Ruijun Zhang, Kevin V. Shianna, et al. “A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.” AIDS 24, no. 1 (January 2, 2010): 155–57. https://doi.org/10.1097/QAD.0b013e32833202f5.
Yoon W, Ma B-J, Fellay J, Huang W, Xia S-M, Zhang R, et al. A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro. AIDS. 2010 Jan 2;24(1):155–7.
Yoon, Woohyun, et al. “A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.” AIDS, vol. 24, no. 1, Jan. 2010, pp. 155–57. Pubmed, doi:10.1097/QAD.0b013e32833202f5.
Yoon W, Ma B-J, Fellay J, Huang W, Xia S-M, Zhang R, Shianna KV, Liao H-X, Haynes BF, Goldstein DB, NIAID Center for HIV/AIDS Vaccine Immunology. A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro. AIDS. 2010 Jan 2;24(1):155–157.
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
January 2, 2010
Volume
24
Issue
1
Start / End Page
155 / 157
Location
England
Related Subject Headings
- Virology
- Viral Load
- RNA, Untranslated
- RNA, Long Noncoding
- Polymorphism, Single Nucleotide
- Major Histocompatibility Complex
- Humans
- HLA-B Antigens
- HIV-1
- HIV Infections