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B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.

Publication ,  Journal Article
Haynes, BF; Moody, MA; Liao, H-X; Verkoczy, L; Tomaras, GD
Published in: Trends Mol Med
February 2011

The B cell arm of the immune response becomes activated soon after HIV-1 transmission, yet the initial antibody response does not control HIV-1 replication, and it takes months for neutralizing antibodies to develop against the autologous virus. Antibodies that can be broadly protective are made only in a minority of subjects and take years to develop--too late to affect the course of disease. New studies of the earliest stages of HIV-1 infection, new techniques to probe the human B cell repertoire, the modest degree of efficacy in a vaccine trial and new studies of human monoclonal antibodies that represent the types of immune responses an HIV-1 vaccine should induce are collectively illuminating paths that a successful HIV-1 vaccine might take.

Duke Scholars

Published In

Trends Mol Med

DOI

EISSN

1471-499X

Publication Date

February 2011

Volume

17

Issue

2

Start / End Page

108 / 116

Location

England

Related Subject Headings

  • Vaccination
  • Mucous Membrane
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • B-Lymphocytes
  • Antibody Formation
 

Citation

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Haynes, B. F., Moody, M. A., Liao, H.-X., Verkoczy, L., & Tomaras, G. D. (2011). B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends Mol Med, 17(2), 108–116. https://doi.org/10.1016/j.molmed.2010.10.008
Haynes, Barton F., M Anthony Moody, Hua-Xin Liao, Laurent Verkoczy, and Georgia D. Tomaras. “B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.Trends Mol Med 17, no. 2 (February 2011): 108–16. https://doi.org/10.1016/j.molmed.2010.10.008.
Haynes BF, Moody MA, Liao H-X, Verkoczy L, Tomaras GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends Mol Med. 2011 Feb;17(2):108–16.
Haynes, Barton F., et al. “B cell responses to HIV-1 infection and vaccination: pathways to preventing infection.Trends Mol Med, vol. 17, no. 2, Feb. 2011, pp. 108–16. Pubmed, doi:10.1016/j.molmed.2010.10.008.
Haynes BF, Moody MA, Liao H-X, Verkoczy L, Tomaras GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends Mol Med. 2011 Feb;17(2):108–116.
Journal cover image

Published In

Trends Mol Med

DOI

EISSN

1471-499X

Publication Date

February 2011

Volume

17

Issue

2

Start / End Page

108 / 116

Location

England

Related Subject Headings

  • Vaccination
  • Mucous Membrane
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • B-Lymphocytes
  • Antibody Formation