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Challenges in the pursuit of immune tolerance.

Publication ,  Journal Article
Nepom, GT; St Clair, EW; Turka, LA
Published in: Immunol Rev
May 2011

Strategies for inducing immune tolerance are fundamentally similar across a spectrum of immune-mediated disorders, including allergic disease, autoimmunity, and rejection of allografts. In each case, the objective of establishing an immunoregulatory balance is challenged by variable upswings in effector cell populations and proinflammatory mediators of immunity, requiring careful, and innovative therapeutic intervention to restore stability. The Immune Tolerance Network, an international consortium sponsored by the National Institutes of Health, seeks to advance both the scientific understanding and the clinical success of immune therapies for these disorders, through an innovative and collaborative effort involving clinical trials and mechanistic studies. Over the last decade, scientists have evaluated cell-based ablation and deviation strategies in trials using lymphocyte-specific targeting, induction of host-donor hematopoietic chimerism, induction of antigen-specific immune regulation, and a variety of antigen desensitization approaches. In this article, we review some of the highlights of this experience and discuss the potential for progress, utilizing new insights into regulatory mechanisms and biomarker signatures of tolerance.

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Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

May 2011

Volume

241

Issue

1

Start / End Page

49 / 62

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Lymphocyte Depletion
  • Immunotherapy
  • Immunomodulation
  • Immunology
  • Immune Tolerance
  • Immune System Diseases
  • Humans
  • Desensitization, Immunologic
  • Clinical Trials as Topic
 

Citation

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Nepom, G. T., St Clair, E. W., & Turka, L. A. (2011). Challenges in the pursuit of immune tolerance. Immunol Rev, 241(1), 49–62. https://doi.org/10.1111/j.1600-065X.2011.01003.x
Nepom, Gerald T., E William St Clair, and Laurence A. Turka. “Challenges in the pursuit of immune tolerance.Immunol Rev 241, no. 1 (May 2011): 49–62. https://doi.org/10.1111/j.1600-065X.2011.01003.x.
Nepom GT, St Clair EW, Turka LA. Challenges in the pursuit of immune tolerance. Immunol Rev. 2011 May;241(1):49–62.
Nepom, Gerald T., et al. “Challenges in the pursuit of immune tolerance.Immunol Rev, vol. 241, no. 1, May 2011, pp. 49–62. Pubmed, doi:10.1111/j.1600-065X.2011.01003.x.
Nepom GT, St Clair EW, Turka LA. Challenges in the pursuit of immune tolerance. Immunol Rev. 2011 May;241(1):49–62.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

May 2011

Volume

241

Issue

1

Start / End Page

49 / 62

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Lymphocyte Depletion
  • Immunotherapy
  • Immunomodulation
  • Immunology
  • Immune Tolerance
  • Immune System Diseases
  • Humans
  • Desensitization, Immunologic
  • Clinical Trials as Topic