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Lymphomatoid Granulomatosis. Prospective clinical and therapeutic experience over 10 years.

Publication ,  Journal Article
Fauci, AS; Haynes, BF; Costa, J; Katz, P; Wolff, SM
Published in: N Engl J Med
January 14, 1982

Fifteen patients with lymphomatoid granulomatosis were studied prospectively over a 10-year period. Thirteen of the patients received the therapeutic protocol of cyclophosphamide (2 mg per kilogram of body weight per day) and prednisone (1 mg per kilogram on alternate days). Previous reports had indicated that mortality from lymphomatoid granulomatosis was as high as 90 per cent. Of the 13 patients who received the cyclophosphamide and prednisone protocol, seven had complete remissions lasting for 5.2 +/- 0.6 years (mean +/- S.E.M.) Six of the seven with disease in remission have received no therapy for 28.3 +/- 5.7 months. Malignant lymphomas developed in seven of the eight who died, and only two of the eight had therapy for an adequate period. Since virtually all patients who did not have complete remission went on to have malignant lymphoma, early recognition and prompt treatment during the lymphomatoid-granulomatosis phase of disease may not only lead to complete remissions but also percent the development of a lymphoid neoplasm.

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Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

January 14, 1982

Volume

306

Issue

2

Start / End Page

68 / 74

Location

United States

Related Subject Headings

  • Prospective Studies
  • Prednisone
  • Middle Aged
  • Male
  • Lymphomatoid Granulomatosis
  • Lymphoma
  • Humans
  • General & Internal Medicine
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Fauci, A. S., Haynes, B. F., Costa, J., Katz, P., & Wolff, S. M. (1982). Lymphomatoid Granulomatosis. Prospective clinical and therapeutic experience over 10 years. N Engl J Med, 306(2), 68–74. https://doi.org/10.1056/NEJM198201143060203
Fauci, A. S., B. F. Haynes, J. Costa, P. Katz, and S. M. Wolff. “Lymphomatoid Granulomatosis. Prospective clinical and therapeutic experience over 10 years.N Engl J Med 306, no. 2 (January 14, 1982): 68–74. https://doi.org/10.1056/NEJM198201143060203.
Fauci AS, Haynes BF, Costa J, Katz P, Wolff SM. Lymphomatoid Granulomatosis. Prospective clinical and therapeutic experience over 10 years. N Engl J Med. 1982 Jan 14;306(2):68–74.
Fauci, A. S., et al. “Lymphomatoid Granulomatosis. Prospective clinical and therapeutic experience over 10 years.N Engl J Med, vol. 306, no. 2, Jan. 1982, pp. 68–74. Pubmed, doi:10.1056/NEJM198201143060203.
Fauci AS, Haynes BF, Costa J, Katz P, Wolff SM. Lymphomatoid Granulomatosis. Prospective clinical and therapeutic experience over 10 years. N Engl J Med. 1982 Jan 14;306(2):68–74.
Journal cover image

Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

January 14, 1982

Volume

306

Issue

2

Start / End Page

68 / 74

Location

United States

Related Subject Headings

  • Prospective Studies
  • Prednisone
  • Middle Aged
  • Male
  • Lymphomatoid Granulomatosis
  • Lymphoma
  • Humans
  • General & Internal Medicine
  • Follow-Up Studies
  • Female