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Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease.

Publication ,  Journal Article
Hooks, JJ; Haynes, BF; Detrick-Hooks, B; Diehl, LF; Gerrard, TL; Fauci, AS
Published in: Blood
January 1982

We report a patient with a disease characterized by proliferation of T cells with Fc receptors for IgG (TG). However, unlike lymphoid cells from normal individuals or from patients with other lymphoid malignancies, the patient's lymphocytes spontaneously produced gamma interferon (IFN-gamma) in vitro. The peripheral lymphocytes consisted of 95% TG cells, which exhibited the morphological characteristics of T-cell chronic lymphocytic leukemia (CLL) and were normal on cytochemical and chromosome analysis. The majority of TG cells were OKT3+, OKT8+, and OKT4-, 3A1-. These cells failed to express suppressor cell activity and displayed depressed levels of natural killer activity, but mediated antibody-dependent cell-mediated cytotoxicity. The spontaneous production of IFN-gamma by human peripheral lymphoid cells as demonstrated in this study may serve as a probe for studying the relationship between IFN-gamma and the proliferation of human T-cell subsets.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

January 1982

Volume

59

Issue

1

Start / End Page

198 / 201

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Fc
  • Middle Aged
  • Male
  • Lymphoproliferative Disorders
  • Leukocytes
  • Leukemia, Lymphoid
  • Interferons
  • Immunology
  • Immunoglobulin G
 

Citation

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MLA
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Hooks, J. J., Haynes, B. F., Detrick-Hooks, B., Diehl, L. F., Gerrard, T. L., & Fauci, A. S. (1982). Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease. Blood, 59(1), 198–201.
Hooks, J. J., B. F. Haynes, B. Detrick-Hooks, L. F. Diehl, T. L. Gerrard, and A. S. Fauci. “Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease.Blood 59, no. 1 (January 1982): 198–201.
Hooks JJ, Haynes BF, Detrick-Hooks B, Diehl LF, Gerrard TL, Fauci AS. Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease. Blood. 1982 Jan;59(1):198–201.
Hooks, J. J., et al. “Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease.Blood, vol. 59, no. 1, Jan. 1982, pp. 198–201.
Hooks JJ, Haynes BF, Detrick-Hooks B, Diehl LF, Gerrard TL, Fauci AS. Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease. Blood. 1982 Jan;59(1):198–201.

Published In

Blood

ISSN

0006-4971

Publication Date

January 1982

Volume

59

Issue

1

Start / End Page

198 / 201

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Fc
  • Middle Aged
  • Male
  • Lymphoproliferative Disorders
  • Leukocytes
  • Leukemia, Lymphoid
  • Interferons
  • Immunology
  • Immunoglobulin G