Scholars@Duke publication: Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis.

Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis.

Publication , Journal Article

Haynes, BF; Miller, SE; Palker, TJ; Moore, JO; Dunn, PH; Bolognesi, DP; Metzgar, RS

Published in: Proc Natl Acad Sci U S A

April 1983

We have identified a Japanese patient with adult T-cell leukemia (ATL) whose T cells in vitro produced the human T-cell leukemia virus (HTLV). This patient presented with lymphomatous arthritis and leukemia and subsequently developed skin lesions. Skin invasion by malignant T-cells was angiocentric and produced vessel wall destruction, resulting in necrotic cutaneous tumor nodules. Malignant T cells in peripheral blood, skin, and joint prior to culture in vitro did not express p19 HTLV-associated antigen. However, by electron microscopy, intracellular type C viral particles were seen in skin-infiltrating T cells. Peripheral blood malignant cells after 7 days in culture with T-cell growth factor-supplemented media expressed p19 antigen, and type C virus particles were seen by electron microscopy to be budding from malignant T lymphocytes. Mitomycin-C-treated peripheral-blood T cells induced the transformation of cord blood T cells into HTLV-infected p19+ T cells. The demonstration of HTLV in malignant T cells from our patient confirms the association of HTLV with Japanese adult T-cell leukemia. Moreover, HTLV may be associated with a vasculitis-arthritis syndrome.

Duke Scholars

Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute

Author Sara Elizabeth Miller Pathology

Author Joseph Odell Moore Medicine, Hematological Malignancies

Author Dani Paul Bolognesi Surgery, Surgical Sciences

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.80.7.2054

ISSN

0027-8424

Publication Date

April 1983

Volume

Issue

Start / End Page

2054 / 2058

Location

United States

Related Subject Headings

Vasculitis
T-Lymphocytes
Retroviridae
Middle Aged
Leukemia
Humans
Female
Antigens, Viral
Antigens, Neoplasm

Citation

APA

Chicago

ICMJE

MLA

NLM

Haynes, B. F., Miller, S. E., Palker, T. J., Moore, J. O., Dunn, P. H., Bolognesi, D. P., & Metzgar, R. S. (1983). Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis. Proc Natl Acad Sci U S A, 80(7), 2054–2058. https://doi.org/10.1073/pnas.80.7.2054

Haynes, B. F., S. E. Miller, T. J. Palker, J. O. Moore, P. H. Dunn, D. P. Bolognesi, and R. S. Metzgar. “Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis.” Proc Natl Acad Sci U S A 80, no. 7 (April 1983): 2054–58. https://doi.org/10.1073/pnas.80.7.2054.

Haynes BF, Miller SE, Palker TJ, Moore JO, Dunn PH, Bolognesi DP, et al. Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis. Proc Natl Acad Sci U S A. 1983 Apr;80(7):2054–8.

Haynes, B. F., et al. “Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis.” Proc Natl Acad Sci U S A, vol. 80, no. 7, Apr. 1983, pp. 2054–58. Pubmed, doi:10.1073/pnas.80.7.2054.

Haynes BF, Miller SE, Palker TJ, Moore JO, Dunn PH, Bolognesi DP, Metzgar RS. Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis. Proc Natl Acad Sci U S A. 1983 Apr;80(7):2054–2058.

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.80.7.2054

ISSN

0027-8424

Publication Date

April 1983

Volume

Issue

Start / End Page

2054 / 2058

Location

United States

Related Subject Headings

Vasculitis
T-Lymphocytes
Retroviridae
Middle Aged
Leukemia
Humans
Female
Antigens, Viral
Antigens, Neoplasm