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Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy.

Publication ,  Journal Article
Stenzel, SL; Krull, KR; Hockenberry, M; Jain, N; Kaemingk, K; Miketova, P; Moore, IM
Published in: Journal of pediatric hematology/oncology
March 2010

Neurobehavioral problems after chemotherapy treatment for pediatric acute lymphoblastic leukemia (ALL) have been a recent focus of investigation. This study extended previous research that suggested oxidative stress as a potential mechanism for chemotherapy-induced central nervous system injury by examining early markers of oxidative stress in relation to subsequent neurobehavioral problems. Oxidized and unoxidized components of phosphatidylcholine (PC) were measured in the cerebrospinal fluid of 87 children with ALL at diagnosis, induction, and consolidation. Behavioral assessments were conducted postconsolidation and at the end of chemotherapy. Results revealed a significant association between physiologic reactivity (high vs. low PC changes from diagnosis) and behavioral outcomes (high vs. low pathology). Elevated oxidized PC fraction change was predictive of increased problems with aggression at the end of therapy as well as postconsolidation adaptability. Furthermore, symptoms of hyperactivity systematically changed over time in relation to both unoxidized PC and oxidized PC fraction reactivity. These findings suggest that symptoms of behavioral problems occur early in the course of chemotherapy and that increases in the cerebrospinal fluid PC markers of oxidative stress during induction and consolidation may help to predict certain future behavioral problems.

Duke Scholars

Published In

Journal of pediatric hematology/oncology

DOI

EISSN

1536-3678

ISSN

1077-4114

Publication Date

March 2010

Volume

32

Issue

2

Start / End Page

113 / 118

Related Subject Headings

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Phosphatidylcholines
  • Oxidative Stress
  • Oxidation-Reduction
  • Oncology & Carcinogenesis
  • Methotrexate
  • Male
  • Humans
  • Female
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Stenzel, S. L., Krull, K. R., Hockenberry, M., Jain, N., Kaemingk, K., Miketova, P., & Moore, I. M. (2010). Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy. Journal of Pediatric Hematology/Oncology, 32(2), 113–118. https://doi.org/10.1097/mph.0b013e3181c9af84
Stenzel, Stephanie L., Kevin R. Krull, Marilyn Hockenberry, Neelam Jain, Kris Kaemingk, Petra Miketova, and Ida M. Moore. “Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy.Journal of Pediatric Hematology/Oncology 32, no. 2 (March 2010): 113–18. https://doi.org/10.1097/mph.0b013e3181c9af84.
Stenzel SL, Krull KR, Hockenberry M, Jain N, Kaemingk K, Miketova P, et al. Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy. Journal of pediatric hematology/oncology. 2010 Mar;32(2):113–8.
Stenzel, Stephanie L., et al. “Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy.Journal of Pediatric Hematology/Oncology, vol. 32, no. 2, Mar. 2010, pp. 113–18. Epmc, doi:10.1097/mph.0b013e3181c9af84.
Stenzel SL, Krull KR, Hockenberry M, Jain N, Kaemingk K, Miketova P, Moore IM. Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy. Journal of pediatric hematology/oncology. 2010 Mar;32(2):113–118.

Published In

Journal of pediatric hematology/oncology

DOI

EISSN

1536-3678

ISSN

1077-4114

Publication Date

March 2010

Volume

32

Issue

2

Start / End Page

113 / 118

Related Subject Headings

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Phosphatidylcholines
  • Oxidative Stress
  • Oxidation-Reduction
  • Oncology & Carcinogenesis
  • Methotrexate
  • Male
  • Humans
  • Female
  • Child, Preschool