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Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus.

Publication ,  Journal Article
Schmitz, JE; Kuroda, MJ; Santra, S; Simon, MA; Lifton, MA; Lin, W; Khunkhun, R; Piatak, M; Lifson, JD; Grosschupff, G; Gelman, RS; Racz, P ...
Published in: J Virol
February 2003

Cellular immune responses mediated by CD8+ lymphocytes exert efficient control of virus replication during primary simian immunodeficiency virus (SIV) infection. However, the role that antibodies may play in the early control of virus replication remains unclear. To evaluate how antibody responses may affect virus replication during primary SIVmac infection, we depleted rhesus monkeys of B cells with anti-CD20 antibody. In normal rhesus monkeys immunized with tetanus toxoid, anti-CD20 treatment and resulting depletion of B cells inhibited the generation of antitetanus antibodies, while tetanus-specific T-cell responses were preserved. During the first 4 weeks after inoculation with SIVmac251, development of SIV-specific neutralizing antibody was delayed, and titers were significantly lower in B-cell-depleted monkeys than control-antibody-treated monkeys. Despite the lower neutralizing antibody titers, the levels of plasma SIV RNA and the linear slope of the decline seen in B-cell-depleted monkeys did not differ from that observed in monkeys treated with control antibody. However, beginning at day 28 after SIV infection, the B-cell-depleted monkeys showed a significant inverse correlation between neutralizing antibody titers and plasma virus level. These results suggest that the rapid decline of peak viremia that typically occurs during the first 3 weeks of infection was not significantly affected by SIV-specific antibodies. However, the inverse correlation between neutralizing antibodies and plasma virus level during the postacute phases of infection suggests that humoral immune responses may contribute to the control of SIV replication.

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

February 2003

Volume

77

Issue

3

Start / End Page

2165 / 2173

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Macaca mulatta
  • Lymphocyte Activation
  • CD8-Positive T-Lymphocytes
  • B-Lymphocytes
  • Antigens, CD20
 

Citation

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Schmitz, J. E., Kuroda, M. J., Santra, S., Simon, M. A., Lifton, M. A., Lin, W., … Reimann, K. A. (2003). Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol, 77(3), 2165–2173. https://doi.org/10.1128/jvi.77.3.2165-2173.2003
Schmitz, Jörn E., Marcelo J. Kuroda, Sampa Santra, Meredith A. Simon, Michelle A. Lifton, Wenyu Lin, Rajinder Khunkhun, et al. “Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus.J Virol 77, no. 3 (February 2003): 2165–73. https://doi.org/10.1128/jvi.77.3.2165-2173.2003.
Schmitz JE, Kuroda MJ, Santra S, Simon MA, Lifton MA, Lin W, et al. Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol. 2003 Feb;77(3):2165–73.
Schmitz, Jörn E., et al. “Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus.J Virol, vol. 77, no. 3, Feb. 2003, pp. 2165–73. Pubmed, doi:10.1128/jvi.77.3.2165-2173.2003.
Schmitz JE, Kuroda MJ, Santra S, Simon MA, Lifton MA, Lin W, Khunkhun R, Piatak M, Lifson JD, Grosschupff G, Gelman RS, Racz P, Tenner-Racz K, Mansfield KA, Letvin NL, Montefiori DC, Reimann KA. Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol. 2003 Feb;77(3):2165–2173.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

February 2003

Volume

77

Issue

3

Start / End Page

2165 / 2173

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Macaca mulatta
  • Lymphocyte Activation
  • CD8-Positive T-Lymphocytes
  • B-Lymphocytes
  • Antigens, CD20