Skip to main content

Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque.

Publication ,  Journal Article
McKenna, PM; Aye, PP; Dietzschold, B; Montefiori, DC; Martin, LN; Marx, PA; Pomerantz, RJ; Lackner, A; Schnell, MJ
Published in: J Virol
December 2004

Rabies virus (RV) has recently been developed as a novel vaccine candidate for human immunodeficiency virus type 1 (HIV-1). The RV glycoprotein (G) can be functionally replaced by HIV-1 envelope glycoprotein (Env) if the gp160 cytoplasmic domain (CD) of HIV-1 Env is replaced by that of RV G. Here, we describe a pilot study of the in vivo replication and immunogenicity of an RV with a deletion of G (DeltaG) expressing a simian/human immunodeficiency virus SHIV(89.6P) Env ectodomain and transmembrane domain fused to the RV G CD (DeltaG-89.6P-RVG) in a rhesus macaque. An animal vaccinated with DeltaG-89.6P-RVG developed SHIV(89.6P) virus-neutralizing antibodies and SHIV(89.6P)-specific cellular immune responses after challenge with SHIV(89.6P). There was no evidence of CD4(+) T-cell loss, and plasma viremia was controlled to undetectable levels by 6 weeks postchallenge and has remained suppressed out to 22 weeks postchallenge.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

December 2004

Volume

78

Issue

24

Start / End Page

13455 / 13459

Location

United States

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Vaccination
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Rabies virus
  • Macaca mulatta
  • Humans
  • HIV-1
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McKenna, P. M., Aye, P. P., Dietzschold, B., Montefiori, D. C., Martin, L. N., Marx, P. A., … Schnell, M. J. (2004). Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque. J Virol, 78(24), 13455–13459. https://doi.org/10.1128/JVI.78.24.13455-13459.2004
McKenna, Philip M., Pyone Pyone Aye, Bernhard Dietzschold, David C. Montefiori, Louis N. Martin, Preston A. Marx, Roger J. Pomerantz, Andrew Lackner, and Matthias J. Schnell. “Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque.J Virol 78, no. 24 (December 2004): 13455–59. https://doi.org/10.1128/JVI.78.24.13455-13459.2004.
McKenna PM, Aye PP, Dietzschold B, Montefiori DC, Martin LN, Marx PA, et al. Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque. J Virol. 2004 Dec;78(24):13455–9.
McKenna, Philip M., et al. “Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque.J Virol, vol. 78, no. 24, Dec. 2004, pp. 13455–59. Pubmed, doi:10.1128/JVI.78.24.13455-13459.2004.
McKenna PM, Aye PP, Dietzschold B, Montefiori DC, Martin LN, Marx PA, Pomerantz RJ, Lackner A, Schnell MJ. Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque. J Virol. 2004 Dec;78(24):13455–13459.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

December 2004

Volume

78

Issue

24

Start / End Page

13455 / 13459

Location

United States

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Vaccination
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Rabies virus
  • Macaca mulatta
  • Humans
  • HIV-1