IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques.
Publication
, Journal Article
O'Neill, E; Bostik, V; Montefiori, DC; Kraiselburd, E; Villinger, F
Published in: AIDS Res Hum Retroviruses
October 2003
Coadministration of pVecB7, a replication-defective SIV DNA vaccine, with interleukin-12 and GM-CSF expression plasmids, induced markedly enhanced control of viral replication and disease-free survival in macaques challenged intrarectally with pathogenic SIVsmE660. Protective mechanisms correlated with broader cell-mediated immune responses to the first two-thirds of the SIV Gag protein and possibly with enhanced SIVsmE660 antibody neutralization at set point, but not with pre- or early postchallenge SIVsmE660 neutralizing antibody production.
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Published In
AIDS Res Hum Retroviruses
DOI
ISSN
0889-2229
Publication Date
October 2003
Volume
19
Issue
10
Start / End Page
883 / 890
Location
United States
Related Subject Headings
- Virology
- Vaccines, DNA
- T-Lymphocytes
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Simian Acquired Immunodeficiency Syndrome
- SAIDS Vaccines
- Macaca mulatta
- Interleukin-12
- Granulocyte-Macrophage Colony-Stimulating Factor
Citation
APA
Chicago
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MLA
NLM
O’Neill, E., Bostik, V., Montefiori, D. C., Kraiselburd, E., & Villinger, F. (2003). IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques. AIDS Res Hum Retroviruses, 19(10), 883–890. https://doi.org/10.1089/088922203322493058
O’Neill, Eduardo, Vanda Bostik, David C. Montefiori, Edmundo Kraiselburd, and François Villinger. “IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques.” AIDS Res Hum Retroviruses 19, no. 10 (October 2003): 883–90. https://doi.org/10.1089/088922203322493058.
O’Neill E, Bostik V, Montefiori DC, Kraiselburd E, Villinger F. IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques. AIDS Res Hum Retroviruses. 2003 Oct;19(10):883–90.
O’Neill, Eduardo, et al. “IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques.” AIDS Res Hum Retroviruses, vol. 19, no. 10, Oct. 2003, pp. 883–90. Pubmed, doi:10.1089/088922203322493058.
O’Neill E, Bostik V, Montefiori DC, Kraiselburd E, Villinger F. IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques. AIDS Res Hum Retroviruses. 2003 Oct;19(10):883–890.
Published In
AIDS Res Hum Retroviruses
DOI
ISSN
0889-2229
Publication Date
October 2003
Volume
19
Issue
10
Start / End Page
883 / 890
Location
United States
Related Subject Headings
- Virology
- Vaccines, DNA
- T-Lymphocytes
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Simian Acquired Immunodeficiency Syndrome
- SAIDS Vaccines
- Macaca mulatta
- Interleukin-12
- Granulocyte-Macrophage Colony-Stimulating Factor