Skip to main content

Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.

Publication ,  Journal Article
Montefiori, DC; Altfeld, M; Lee, PK; Bilska, M; Zhou, J; Johnston, MN; Gao, F; Walker, BD; Rosenberg, ES
Published in: J Immunol
April 1, 2003

The neutralizing Ab response after primary HIV-1 infection is delayed relative to the virus-specific CD8(+) T cell response and the initial decline in plasma viremia. Because nearly all HIV-1 infections result in AIDS, it would be instructive to study cases where neutralizing Ab production commenced sooner. This was done in subject AC10, an individual treated during early infection and in whom a rapid autologous neutralizing Ab response was detected after therapy cessation as rebound viremia declined and remained below 1000 RNA copies/ml of blood for over 2.5 years. This subject's Abs were capable of reducing the infectivity of his rebound virus by >4 logs in vitro at a time when rebound viremia was down-regulated and virus-specific CD8(+) T cells were minimal, suggesting that neutralizing Abs played an important role in the early control of viremia. The rebound virus did not exhibit an unusual phenotype that might explain its high sensitivity to neutralization by autologous sera. Neutralization escape occurred within 75 days and was proceeded by neutralizing Ab production to the escape variant and subsequent escape. Notably, escape was not associated with a significant rise in plasma viremia, perhaps due to increasing CD8(+) T cell responses. Sequence analysis of gp160 revealed a growing number of mutations over time, suggesting ongoing viral evolution in the face of potent antiviral immune responses. We postulate that an early effective neutralizing Ab response can provide long-term clinical benefits despite neutralization escape.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

April 1, 2003

Volume

170

Issue

7

Start / End Page

3906 / 3914

Location

United States

Related Subject Headings

  • Virus Replication
  • Viremia
  • Peptide Fragments
  • Neutralization Tests
  • Molecular Sequence Data
  • Male
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Montefiori, D. C., Altfeld, M., Lee, P. K., Bilska, M., Zhou, J., Johnston, M. N., … Rosenberg, E. S. (2003). Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual. J Immunol, 170(7), 3906–3914. https://doi.org/10.4049/jimmunol.170.7.3906
Montefiori, David C., Marcus Altfeld, Paul K. Lee, Miroslawa Bilska, Jintao Zhou, Mary N. Johnston, Feng Gao, Bruce D. Walker, and Eric S. Rosenberg. “Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.J Immunol 170, no. 7 (April 1, 2003): 3906–14. https://doi.org/10.4049/jimmunol.170.7.3906.
Montefiori DC, Altfeld M, Lee PK, Bilska M, Zhou J, Johnston MN, et al. Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual. J Immunol. 2003 Apr 1;170(7):3906–14.
Montefiori, David C., et al. “Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.J Immunol, vol. 170, no. 7, Apr. 2003, pp. 3906–14. Pubmed, doi:10.4049/jimmunol.170.7.3906.
Montefiori DC, Altfeld M, Lee PK, Bilska M, Zhou J, Johnston MN, Gao F, Walker BD, Rosenberg ES. Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual. J Immunol. 2003 Apr 1;170(7):3906–3914.

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

April 1, 2003

Volume

170

Issue

7

Start / End Page

3906 / 3914

Location

United States

Related Subject Headings

  • Virus Replication
  • Viremia
  • Peptide Fragments
  • Neutralization Tests
  • Molecular Sequence Data
  • Male
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections