Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells.
Publication
, Journal Article
Robinson, HL; Sharma, S; Zhao, J; Kannanganat, S; Lai, L; Chennareddi, L; Yu, T; Montefiori, DC; Amara, RR; Wyatt, LS; Moss, B
Published in: AIDS Res Hum Retroviruses
December 2007
The clinical product for a clade B HIV DNA/MVA vaccine expressing Gag, Pol, and Env has been tested for immunogenicity in macaques. Responding T cells were at the threshold for detection following DNA priming at weeks 0 and 8 but underwent sharp expansions and contractions following MVA boosting at weeks 16 and 24. Both CD4 and CD8 T cell responses had high frequencies of cytokine coproducing cells with >50% of the memory cells coproducing multiple cytokines including IL-2. The highest responses were elicited to Gag, followed by Env and then Pol. In two of six macaques, the vaccine also elicited low levels of neutralizing Ab for easy to neutralize clade B isolates.
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Published In
AIDS Res Hum Retroviruses
DOI
ISSN
0889-2229
Publication Date
December 2007
Volume
23
Issue
12
Start / End Page
1555 / 1562
Location
United States
Related Subject Headings
- Virology
- Vaccines, DNA
- Tumor Necrosis Factor-alpha
- Macaca
- Interleukin-2
- Interferon-gamma
- Cytokines
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
- Animals
Citation
APA
Chicago
ICMJE
MLA
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Robinson, H. L., Sharma, S., Zhao, J., Kannanganat, S., Lai, L., Chennareddi, L., … Moss, B. (2007). Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells. AIDS Res Hum Retroviruses, 23(12), 1555–1562. https://doi.org/10.1089/aid.2007.0165
Robinson, Harriet L., Sunita Sharma, Jun Zhao, Sunil Kannanganat, Lilin Lai, Lakshmi Chennareddi, Tianwei Yu, et al. “Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells.” AIDS Res Hum Retroviruses 23, no. 12 (December 2007): 1555–62. https://doi.org/10.1089/aid.2007.0165.
Robinson HL, Sharma S, Zhao J, Kannanganat S, Lai L, Chennareddi L, et al. Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells. AIDS Res Hum Retroviruses. 2007 Dec;23(12):1555–62.
Robinson, Harriet L., et al. “Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells.” AIDS Res Hum Retroviruses, vol. 23, no. 12, Dec. 2007, pp. 1555–62. Pubmed, doi:10.1089/aid.2007.0165.
Robinson HL, Sharma S, Zhao J, Kannanganat S, Lai L, Chennareddi L, Yu T, Montefiori DC, Amara RR, Wyatt LS, Moss B. Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells. AIDS Res Hum Retroviruses. 2007 Dec;23(12):1555–1562.
Published In
AIDS Res Hum Retroviruses
DOI
ISSN
0889-2229
Publication Date
December 2007
Volume
23
Issue
12
Start / End Page
1555 / 1562
Location
United States
Related Subject Headings
- Virology
- Vaccines, DNA
- Tumor Necrosis Factor-alpha
- Macaca
- Interleukin-2
- Interferon-gamma
- Cytokines
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
- Animals