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Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.

Publication ,  Journal Article
Letvin, NL; Mascola, JR; Sun, Y; Gorgone, DA; Buzby, AP; Xu, L; Yang, Z-Y; Chakrabarti, B; Rao, SS; Schmitz, JE; Montefiori, DC; Barker, BR ...
Published in: Science
June 9, 2006

Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.

Duke Scholars

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 9, 2006

Volume

312

Issue

5779

Start / End Page

1530 / 1533

Location

United States

Related Subject Headings

  • Virus Replication
  • Vaccines, Synthetic
  • Vaccines, DNA
  • Survival Analysis
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Plasmids
  • Molecular Sequence Data
 

Citation

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Letvin, N. L., Mascola, J. R., Sun, Y., Gorgone, D. A., Buzby, A. P., Xu, L., … Nabel, G. J. (2006). Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science, 312(5779), 1530–1533. https://doi.org/10.1126/science.1124226
Letvin, Norman L., John R. Mascola, Yue Sun, Darci A. Gorgone, Adam P. Buzby, Ling Xu, Zhi-Yong Yang, et al. “Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.Science 312, no. 5779 (June 9, 2006): 1530–33. https://doi.org/10.1126/science.1124226.
Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L, et al. Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science. 2006 Jun 9;312(5779):1530–3.
Letvin, Norman L., et al. “Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.Science, vol. 312, no. 5779, June 2006, pp. 1530–33. Pubmed, doi:10.1126/science.1124226.
Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L, Yang Z-Y, Chakrabarti B, Rao SS, Schmitz JE, Montefiori DC, Barker BR, Bookstein FL, Nabel GJ. Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science. 2006 Jun 9;312(5779):1530–1533.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

June 9, 2006

Volume

312

Issue

5779

Start / End Page

1530 / 1533

Location

United States

Related Subject Headings

  • Virus Replication
  • Vaccines, Synthetic
  • Vaccines, DNA
  • Survival Analysis
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Plasmids
  • Molecular Sequence Data