Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
Publication
, Journal Article
Amara, RR; Villinger, F; Altman, JD; Lydy, SL; O'Neil, SP; Staprans, SI; Montefiori, DC; Xu, Y; Herndon, JG; Wyatt, LS; Candido, MA; Kozyr, NL ...
Published in: Vaccine
May 6, 2002
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here, we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a Rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These highly promising findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic.
Duke Scholars
Published In
Vaccine
DOI
ISSN
0264-410X
Publication Date
May 6, 2002
Volume
20
Issue
15
Start / End Page
1949 / 1955
Location
Netherlands
Related Subject Headings
- Virulence
- Virology
- Viral Load
- Vaccinia virus
- Vaccines, Synthetic
- Vaccines, DNA
- Vaccination
- Simian Acquired Immunodeficiency Syndrome
- Rectum
- Macaca mulatta
Citation
APA
Chicago
ICMJE
MLA
NLM
Amara, R. R., Villinger, F., Altman, J. D., Lydy, S. L., O’Neil, S. P., Staprans, S. I., … Robinson, H. L. (2002). Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Vaccine, 20(15), 1949–1955. https://doi.org/10.1016/s0264-410x(02)00076-2
Amara, Rama Rao, Francois Villinger, John D. Altman, Shari L. Lydy, Shawn P. O’Neil, Silvija I. Staprans, David C. Montefiori, et al. “Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.” Vaccine 20, no. 15 (May 6, 2002): 1949–55. https://doi.org/10.1016/s0264-410x(02)00076-2.
Amara RR, Villinger F, Altman JD, Lydy SL, O’Neil SP, Staprans SI, et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Vaccine. 2002 May 6;20(15):1949–55.
Amara, Rama Rao, et al. “Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.” Vaccine, vol. 20, no. 15, May 2002, pp. 1949–55. Pubmed, doi:10.1016/s0264-410x(02)00076-2.
Amara RR, Villinger F, Altman JD, Lydy SL, O’Neil SP, Staprans SI, Montefiori DC, Xu Y, Herndon JG, Wyatt LS, Candido MA, Kozyr NL, Earl PL, Smith JM, Ma H-L, Grimm BD, Hulsey ML, McClure HM, McNicholl JM, Moss B, Robinson HL. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Vaccine. 2002 May 6;20(15):1949–1955.
Published In
Vaccine
DOI
ISSN
0264-410X
Publication Date
May 6, 2002
Volume
20
Issue
15
Start / End Page
1949 / 1955
Location
Netherlands
Related Subject Headings
- Virulence
- Virology
- Viral Load
- Vaccinia virus
- Vaccines, Synthetic
- Vaccines, DNA
- Vaccination
- Simian Acquired Immunodeficiency Syndrome
- Rectum
- Macaca mulatta