Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.
Publication
, Journal Article
Haynes, BF; Montefiori, DC
Published in: Expert Rev Vaccines
August 2006
Neutralizing antibody induction is a key feature of many effective vaccines and is the only immune response that has proven to be capable of completely blocking AIDS virus infection in animal models. Unfortunately, the extensive genetic variability and complex immune-evasion strategies of HIV-1 have thwarted all attempts to date at eliciting an effective neutralizing antibody response with candidate HIV-1 vaccine immunogens. Recent advances in our understanding of how these evasion strategies operate, coupled with growing progress in unravelling the structure and immunobiology of the viral envelope glycoproteins, are contributing to novel immunogen designs to overcome the many barriers to inducing protective antibodies against HIV-1.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Expert Rev Vaccines
DOI
EISSN
1744-8395
Publication Date
August 2006
Volume
5
Issue
4
Start / End Page
579 / 595
Location
England
Related Subject Headings
- Virology
- Sensitivity and Specificity
- Neutralization Tests
- Humans
- HIV Infections
- Drug Design
- Antibody Formation
- Antibodies, Viral
- AIDS Vaccines
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Haynes, B. F., & Montefiori, D. C. (2006). Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev Vaccines, 5(4), 579–595. https://doi.org/10.1586/14760584.5.4.579
Haynes, Barton F., and David C. Montefiori. “Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.” Expert Rev Vaccines 5, no. 4 (August 2006): 579–95. https://doi.org/10.1586/14760584.5.4.579.
Haynes BF, Montefiori DC. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev Vaccines. 2006 Aug;5(4):579–95.
Haynes, Barton F., and David C. Montefiori. “Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.” Expert Rev Vaccines, vol. 5, no. 4, Aug. 2006, pp. 579–95. Pubmed, doi:10.1586/14760584.5.4.579.
Haynes BF, Montefiori DC. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev Vaccines. 2006 Aug;5(4):579–595.
Published In
Expert Rev Vaccines
DOI
EISSN
1744-8395
Publication Date
August 2006
Volume
5
Issue
4
Start / End Page
579 / 595
Location
England
Related Subject Headings
- Virology
- Sensitivity and Specificity
- Neutralization Tests
- Humans
- HIV Infections
- Drug Design
- Antibody Formation
- Antibodies, Viral
- AIDS Vaccines
- 3204 Immunology