Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.
Publication
, Journal Article
Haynes, BF; Montefiori, DC
Published in: Expert Rev Vaccines
June 2006
Neutralizing antibody induction is a key feature of many effective vaccines and is the only immune response that has proven to be capable of completely blocking AIDS virus infection in animal models. Unfortunately, the extensive genetic variability and complex immune-evasion strategies of HIV-1 have thwarted all attempts to date at eliciting an effective neutralizing antibody response with candidate HIV-1 vaccine immunogens. Recent advances in our understanding of how these evasion strategies operate, coupled with growing progress in unravelling the structure and immunobiology of the viral envelope glycoproteins, are contributing to novel immunogen designs to overcome the many barriers to inducing protective antibodies against HIV-1.
Duke Scholars
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Published In
Expert Rev Vaccines
DOI
EISSN
1744-8395
Publication Date
June 2006
Volume
5
Issue
3
Start / End Page
347 / 363
Location
England
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Protein Conformation
- Humans
- HIV-1
- HIV Infections
- HIV Envelope Protein gp41
- HIV Envelope Protein gp120
- HIV Antibodies
- Gene Products, env
Citation
APA
Chicago
ICMJE
MLA
NLM
Haynes, B. F., & Montefiori, D. C. (2006). Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev Vaccines, 5(3), 347–363. https://doi.org/10.1586/14760584.5.3.347
Haynes, Barton F., and David C. Montefiori. “Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.” Expert Rev Vaccines 5, no. 3 (June 2006): 347–63. https://doi.org/10.1586/14760584.5.3.347.
Haynes BF, Montefiori DC. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev Vaccines. 2006 Jun;5(3):347–63.
Haynes, Barton F., and David C. Montefiori. “Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.” Expert Rev Vaccines, vol. 5, no. 3, June 2006, pp. 347–63. Pubmed, doi:10.1586/14760584.5.3.347.
Haynes BF, Montefiori DC. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev Vaccines. 2006 Jun;5(3):347–363.
Published In
Expert Rev Vaccines
DOI
EISSN
1744-8395
Publication Date
June 2006
Volume
5
Issue
3
Start / End Page
347 / 363
Location
England
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Protein Conformation
- Humans
- HIV-1
- HIV Infections
- HIV Envelope Protein gp41
- HIV Envelope Protein gp120
- HIV Antibodies
- Gene Products, env