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C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy.

Publication ,  Journal Article
Krasuski, RA; Bush, A; Kay, JE; Mayes, CE; Wang, A; Fleming, J; Pierce, C; Kisslo, KB; Harrison, JK; Bashore, TM
Published in: Am Heart J
December 2003

BACKGROUND: Markers of systemic inflammation including C-reactive protein (CRP) appear to predict morbidity and mortality in various clinical conditions. The presence of systemic inflammation and its impact on the procedural success of percutaneous balloon mitral valve commissurotomy (PBMC) in patients with rheumatic mitral stenosis has not been previously demonstrated. METHODS: Measurements of CRP with a high-sensitivity assay were performed at the time of PBMC or during post-procedural follow-up in 119 patients with mitral stenosis of rheumatic morphology. Patients were questioned to exclude confounders of CRP elevation and categorized into undetectable (< or =0.10 mg/L) and detectable (>0.10 mg/L) CRP levels. Detectable levels were further classified into assay range (>0.10 and < or =6.0 mg/L) and elevated (>6.0 mg/L). RESULTS: CRP was detectable in 76% of patients and elevated (>6.0 mg/L) in 36% of patients studied. Procedural success occurred in 89% of patients with undetectable CRP, as compared with only 67% in patients with detectable CRP (P =.028). This effect remained after controlling for age and valve score (previously described predictors of PBMC success). CONCLUSIONS: Systemic inflammation is common in patients with rheumatic mitral valve stenosis, and the relationship between procedural success and CRP suggests persistent inflammation may affect the results of PBMC.

Duke Scholars

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

December 2003

Volume

146

Issue

6

Start / End Page

1099 / 1104

Location

United States

Related Subject Headings

  • Ultrasonography
  • Statistics as Topic
  • Rheumatic Heart Disease
  • Mitral Valve Stenosis
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Female
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
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Krasuski, R. A., Bush, A., Kay, J. E., Mayes, C. E., Wang, A., Fleming, J., … Bashore, T. M. (2003). C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy. Am Heart J, 146(6), 1099–1104. https://doi.org/10.1016/S0002-8703(03)00506-4
Krasuski, Richard A., Anneke Bush, Joseph E. Kay, Charles E. Mayes, Andrew Wang, Judy Fleming, Cynthia Pierce, Katherine B. Kisslo, J Kevin Harrison, and Thomas M. Bashore. “C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy.Am Heart J 146, no. 6 (December 2003): 1099–1104. https://doi.org/10.1016/S0002-8703(03)00506-4.
Krasuski RA, Bush A, Kay JE, Mayes CE, Wang A, Fleming J, et al. C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy. Am Heart J. 2003 Dec;146(6):1099–104.
Krasuski, Richard A., et al. “C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy.Am Heart J, vol. 146, no. 6, Dec. 2003, pp. 1099–104. Pubmed, doi:10.1016/S0002-8703(03)00506-4.
Krasuski RA, Bush A, Kay JE, Mayes CE, Wang A, Fleming J, Pierce C, Kisslo KB, Harrison JK, Bashore TM. C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy. Am Heart J. 2003 Dec;146(6):1099–1104.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

December 2003

Volume

146

Issue

6

Start / End Page

1099 / 1104

Location

United States

Related Subject Headings

  • Ultrasonography
  • Statistics as Topic
  • Rheumatic Heart Disease
  • Mitral Valve Stenosis
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Female
  • Cardiovascular System & Hematology