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Therapy for non-clear cell histologies in renal cancer.

Publication ,  Journal Article
Bitting, RL; Madden, J; Armstrong, AJ
Published in: Curr Clin Pharmacol
August 2011

The advent of targeted systemic therapies has significantly improved treatment options for patients with metastatic renal cell carcinoma (RCC). Multiple agents that inhibit angiogenesis cell growth and proliferation via the VEGF and mTOR (TORC1) pathways have been USFDA-approved for locally advanced or metastatic renal cell carcinoma in recent years although the majority of clinical trials have focused only on clear cell RCC. While clear cell RCC is the most common histologic subtype nearly 25% of RCC cases are histologic variants representing a diverse group of diseases with different prognoses underlying biology and molecular targets and therapies. This review will focus on the incidence clinical and pathologic features pathogenesis and treatment strategies of non-clear cell RCC in both the adjuvant and metastatic setting. These non-clear cell subtypes include papillary type 1 and type 2 chromophobe translocation carcinoma and collecting duct RCC. Controlled studies in these relatively rare subgroups are needed to inform upon clinical practice which is currently based on small series of uncontrolled studies. Ongoing clinical trials and areas of future research will be discussed.

Duke Scholars

Published In

Curr Clin Pharmacol

DOI

EISSN

2212-3938

Publication Date

August 2011

Volume

6

Issue

3

Start / End Page

169 / 180

Location

United Arab Emirates

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • TOR Serine-Threonine Kinases
  • Signal Transduction
  • Pharmacology & Pharmacy
  • Kidney Neoplasms
  • Humans
  • Clinical Trials as Topic
  • Carcinoma, Renal Cell
  • Antineoplastic Agents
  • Animals
 

Citation

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MLA
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Bitting, R. L., Madden, J., & Armstrong, A. J. (2011). Therapy for non-clear cell histologies in renal cancer. Curr Clin Pharmacol, 6(3), 169–180. https://doi.org/10.2174/157488411797189460
Bitting, Rhonda L., John Madden, and Andrew J. Armstrong. “Therapy for non-clear cell histologies in renal cancer.Curr Clin Pharmacol 6, no. 3 (August 2011): 169–80. https://doi.org/10.2174/157488411797189460.
Bitting RL, Madden J, Armstrong AJ. Therapy for non-clear cell histologies in renal cancer. Curr Clin Pharmacol. 2011 Aug;6(3):169–80.
Bitting, Rhonda L., et al. “Therapy for non-clear cell histologies in renal cancer.Curr Clin Pharmacol, vol. 6, no. 3, Aug. 2011, pp. 169–80. Pubmed, doi:10.2174/157488411797189460.
Bitting RL, Madden J, Armstrong AJ. Therapy for non-clear cell histologies in renal cancer. Curr Clin Pharmacol. 2011 Aug;6(3):169–180.

Published In

Curr Clin Pharmacol

DOI

EISSN

2212-3938

Publication Date

August 2011

Volume

6

Issue

3

Start / End Page

169 / 180

Location

United Arab Emirates

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • TOR Serine-Threonine Kinases
  • Signal Transduction
  • Pharmacology & Pharmacy
  • Kidney Neoplasms
  • Humans
  • Clinical Trials as Topic
  • Carcinoma, Renal Cell
  • Antineoplastic Agents
  • Animals