Skip to main content

Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection.

Publication ,  Journal Article
Yates, NL; Lucas, JT; Nolen, TL; Vandergrift, NA; Soderberg, KA; Seaton, KE; Denny, TN; Haynes, BF; Cohen, MS; Tomaras, GD
Published in: AIDS
November 13, 2011

OBJECTIVE: Different HIV-1 antigen specificities appear in sequence after HIV-1 transmission and the immunoglobulin G (IgG) subclass responses to HIV antigens are distinct from each other. The initial predominant IgG subclass response to HIV-1 infection consists of IgG1 and IgG3 antibodies with a noted decline in some IgG3 antibodies during acute HIV-1 infection. Thus, we postulate that multiple antigen-specific IgG3 responses may serve as surrogates for the relative time since HIV-1 acquisition. DESIGN: We determined the magnitude, peak, and half-life of HIV-1 antigen-specific IgG1 and IgG3 antibodies in 41 HIV-1-infected individuals followed longitudinally from acute infection during the first appearance of HIV-1-specific antibodies through approximately 6 months after infection. METHODS: We used quantitative HIV-1-binding antibody multiplex assays and exponential decay models to estimate concentrations of IgG1 and IgG3 antibodies to eight different HIV-1 proteins including gp140 Env, gp120 Env, gp41 Env, p66 reverse transcriptase, p31 Integrase, Tat, Nef, and p55 Gag proteins during acute/recent HIV-1 infection. RESULTS: Among HIV-1-specific IgG3 responses, anti-gp41 IgG3 antibodies were the first to appear. We found that anti-gp41 Env IgG3 and anti-p66 reverse transcriptase IgG3 antibodies, in addition to anti-Gag IgG3 antibodies, each consistently and measurably declined after acute infection, in contrast to the persistent antigen-specific IgG1 responses. CONCLUSION: The detailed measurements of the decline in multiple HIV-specific IgG3 responses simultaneous with persistent IgG1 responses during acute and recent HIV-1 infection could serve as markers for detection of incident HIV infection.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

AIDS

DOI

EISSN

1473-5571

Publication Date

November 13, 2011

Volume

25

Issue

17

Start / End Page

2089 / 2097

Location

England

Related Subject Headings

  • Young Adult
  • Virology
  • Viral Load
  • Time Factors
  • Middle Aged
  • Male
  • Immunoglobulin G
  • Humans
  • HIV-1
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yates, N. L., Lucas, J. T., Nolen, T. L., Vandergrift, N. A., Soderberg, K. A., Seaton, K. E., … Tomaras, G. D. (2011). Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection. AIDS, 25(17), 2089–2097. https://doi.org/10.1097/QAD.0b013e32834b348e
Yates, Nicole L., Judith T. Lucas, Tracy L. Nolen, Nathan A. Vandergrift, Kelly A. Soderberg, Kelly E. Seaton, Thomas N. Denny, Barton F. Haynes, Myron S. Cohen, and Georgia D. Tomaras. “Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection.AIDS 25, no. 17 (November 13, 2011): 2089–97. https://doi.org/10.1097/QAD.0b013e32834b348e.
Yates NL, Lucas JT, Nolen TL, Vandergrift NA, Soderberg KA, Seaton KE, et al. Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection. AIDS. 2011 Nov 13;25(17):2089–97.
Yates, Nicole L., et al. “Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection.AIDS, vol. 25, no. 17, Nov. 2011, pp. 2089–97. Pubmed, doi:10.1097/QAD.0b013e32834b348e.
Yates NL, Lucas JT, Nolen TL, Vandergrift NA, Soderberg KA, Seaton KE, Denny TN, Haynes BF, Cohen MS, Tomaras GD. Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection. AIDS. 2011 Nov 13;25(17):2089–2097.

Published In

AIDS

DOI

EISSN

1473-5571

Publication Date

November 13, 2011

Volume

25

Issue

17

Start / End Page

2089 / 2097

Location

England

Related Subject Headings

  • Young Adult
  • Virology
  • Viral Load
  • Time Factors
  • Middle Aged
  • Male
  • Immunoglobulin G
  • Humans
  • HIV-1
  • HIV Infections