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Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting.

Publication ,  Journal Article
Ostrosky-Zeichner, L; Sable, C; Sobel, J; Alexander, BD; Donowitz, G; Kan, V; Kauffman, CA; Kett, D; Larsen, RA; Morrison, V; Nucci, M ...
Published in: Eur J Clin Microbiol Infect Dis
April 2007

The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting. Retrospective review and statistical modelling were carried out on 2,890 patients who stayed at least 4 days in nine hospitals in the USA and Brazil; the overall incidence of invasive candidiasis in this group was 3% (88 cases). The best performing rule was as follows: Any systemic antibiotic (days 1-3) OR presence of a central venous catheter (days 1-3) AND at least TWO of the following-total parenteral nutrition (days 1-3), any dialysis (days 1-3), any major surgery (days -7-0), pancreatitis (days -7-0), any use of steroids (days -7-3), or use of other immunosuppressive agents (days -7-0). The rate of invasive candidiasis among patients meeting the rule was 9.9%, capturing 34% of cases in the units, with the following performance: relative risk 4.36, sensitivity 0.34, specificity 0.90, positive predictive value 0.01, and negative predictive value 0.97. The rule may identify patients at high risk of invasive candidiasis.

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Published In

Eur J Clin Microbiol Infect Dis

DOI

ISSN

0934-9723

Publication Date

April 2007

Volume

26

Issue

4

Start / End Page

271 / 276

Location

Germany

Related Subject Headings

  • United States
  • Sensitivity and Specificity
  • Risk Factors
  • Retrospective Studies
  • Reproducibility of Results
  • Predictive Value of Tests
  • Models, Statistical
  • Middle Aged
  • Microbiology
  • Male
 

Citation

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ICMJE
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Ostrosky-Zeichner, L., Sable, C., Sobel, J., Alexander, B. D., Donowitz, G., Kan, V., … Rex, J. H. (2007). Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis, 26(4), 271–276. https://doi.org/10.1007/s10096-007-0270-z
Ostrosky-Zeichner, L., C. Sable, J. Sobel, B. D. Alexander, G. Donowitz, V. Kan, C. A. Kauffman, et al. “Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting.Eur J Clin Microbiol Infect Dis 26, no. 4 (April 2007): 271–76. https://doi.org/10.1007/s10096-007-0270-z.
Ostrosky-Zeichner L, Sable C, Sobel J, Alexander BD, Donowitz G, Kan V, et al. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis. 2007 Apr;26(4):271–6.
Ostrosky-Zeichner, L., et al. “Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting.Eur J Clin Microbiol Infect Dis, vol. 26, no. 4, Apr. 2007, pp. 271–76. Pubmed, doi:10.1007/s10096-007-0270-z.
Ostrosky-Zeichner L, Sable C, Sobel J, Alexander BD, Donowitz G, Kan V, Kauffman CA, Kett D, Larsen RA, Morrison V, Nucci M, Pappas PG, Bradley ME, Major S, Zimmer L, Wallace D, Dismukes WE, Rex JH. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis. 2007 Apr;26(4):271–276.
Journal cover image

Published In

Eur J Clin Microbiol Infect Dis

DOI

ISSN

0934-9723

Publication Date

April 2007

Volume

26

Issue

4

Start / End Page

271 / 276

Location

Germany

Related Subject Headings

  • United States
  • Sensitivity and Specificity
  • Risk Factors
  • Retrospective Studies
  • Reproducibility of Results
  • Predictive Value of Tests
  • Models, Statistical
  • Middle Aged
  • Microbiology
  • Male