Molecular identification of Aspergillus species collected for the Transplant-Associated Infection Surveillance Network.
A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and beta-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.
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- Tubulin
- Transplantation
- Sequence Analysis, DNA
- Microbiology
- Microbial Sensitivity Tests
- Immunocompromised Host
- Humans
- DNA, Ribosomal Spacer
- DNA, Fungal
- Aspergillus
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tubulin
- Transplantation
- Sequence Analysis, DNA
- Microbiology
- Microbial Sensitivity Tests
- Immunocompromised Host
- Humans
- DNA, Ribosomal Spacer
- DNA, Fungal
- Aspergillus