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A phase II trial of carboplatin/vinorelbine with pegfilgrastim support for the treatment of patients with advanced non-small cell lung cancer.

Publication ,  Journal Article
Riedel, RF; Andrews, C; Garst, J; Dunphy, F; Herndon, JE; Blackwell, S; Barbour, S; Crawford, J
Published in: J Thorac Oncol
June 2007

INTRODUCTION: The impact of chemotherapy dose delivery has not been well studied in patients with non-small cell lung cancer (NSCLC). Overlapping hematologic toxicities commonly limit planned dose intensity of combination chemotherapy regimens. A phase II study investigating carboplatin and vinorelbine, supported by pegfilgrastim, in the treatment of patients with advanced NSCLC was performed. METHODS: Chemotherapy-naïve patients with locally advanced or metastatic NSCLC were treated with carboplatin area under the curve (AUC) 6 mg/ml per minute intravenously on day 1 and vinorelbine 30 mg/m2 intravenously on days 1 and 8 every 3 weeks for four planned cycles. Pegfilgrastim was administered on day 9 of each cycle as a 6-mg subcutaneous injection. The primary endpoint was incidence of cycle 1 febrile neutropenia. Secondary endpoints included incidence of grade 3/4 hematologic and nonhematologic toxicities, delivered dose intensity, and overall survival. RESULTS: Thirty patients (21 men, 9 women) with a median age of 61 years (range, 43-79) were enrolled. Of 120 planned patient cycles, 101 (84%) were completed. There was one episode of cycle 1 febrile neutropenia. Overall response rate was 27%. Median dose delivered for vinorelbine was 17.2 mg/m2 per week, representing a delivered dose intensity of 86%. Median survival was 9.4 months (95% confidence interval: 6.1-18.0) with a 3-year survival rate of 20%. CONCLUSIONS: This regimen of carboplatin and vinorelbine with pegfilgrastim support was associated with a low rate of febrile neutropenia and good maintenance of planned dose intensity. Although response and survival are similar to other chemotherapy regimens in advanced NSCLC, studies optimizing chemotherapy delivery in this setting may help inform treatment approaches in patients with earlier stage disease.

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Published In

J Thorac Oncol

DOI

EISSN

1556-1380

Publication Date

June 2007

Volume

2

Issue

6

Start / End Page

520 / 525

Location

United States

Related Subject Headings

  • Vinblastine
  • Treatment Outcome
  • Survival Rate
  • Recombinant Proteins
  • Prognosis
  • Polyethylene Glycols
  • Oncology & Carcinogenesis
  • Neutropenia
  • Middle Aged
  • Male
 

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Riedel, R. F., Andrews, C., Garst, J., Dunphy, F., Herndon, J. E., Blackwell, S., … Crawford, J. (2007). A phase II trial of carboplatin/vinorelbine with pegfilgrastim support for the treatment of patients with advanced non-small cell lung cancer. J Thorac Oncol, 2(6), 520–525. https://doi.org/10.1097/JTO.0b013e318060107c
Riedel, Richard F., Carolyn Andrews, Jennifer Garst, Frank Dunphy, James E. Herndon, Susan Blackwell, Sally Barbour, and Jeffrey Crawford. “A phase II trial of carboplatin/vinorelbine with pegfilgrastim support for the treatment of patients with advanced non-small cell lung cancer.J Thorac Oncol 2, no. 6 (June 2007): 520–25. https://doi.org/10.1097/JTO.0b013e318060107c.
Riedel RF, Andrews C, Garst J, Dunphy F, Herndon JE, Blackwell S, et al. A phase II trial of carboplatin/vinorelbine with pegfilgrastim support for the treatment of patients with advanced non-small cell lung cancer. J Thorac Oncol. 2007 Jun;2(6):520–5.
Riedel, Richard F., et al. “A phase II trial of carboplatin/vinorelbine with pegfilgrastim support for the treatment of patients with advanced non-small cell lung cancer.J Thorac Oncol, vol. 2, no. 6, June 2007, pp. 520–25. Pubmed, doi:10.1097/JTO.0b013e318060107c.
Riedel RF, Andrews C, Garst J, Dunphy F, Herndon JE, Blackwell S, Barbour S, Crawford J. A phase II trial of carboplatin/vinorelbine with pegfilgrastim support for the treatment of patients with advanced non-small cell lung cancer. J Thorac Oncol. 2007 Jun;2(6):520–525.
Journal cover image

Published In

J Thorac Oncol

DOI

EISSN

1556-1380

Publication Date

June 2007

Volume

2

Issue

6

Start / End Page

520 / 525

Location

United States

Related Subject Headings

  • Vinblastine
  • Treatment Outcome
  • Survival Rate
  • Recombinant Proteins
  • Prognosis
  • Polyethylene Glycols
  • Oncology & Carcinogenesis
  • Neutropenia
  • Middle Aged
  • Male