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Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004.

Publication ,  Journal Article
Al-Khatib, SM; Sanders, GD; Mark, DB; Lee, KL; Bardy, GH; Bigger, JT; Buxton, AE; Connolly, S; Kadish, A; Moss, A; Feldman, AM; Ellenbogen, KA ...
Published in: Am Heart J
June 2005

Although many studies have shown that implantable cardioverter defibrillator (ICD) therapy improves the survival of patients with significant left ventricular dysfunction, the magnitude of effectiveness of ICD therapy in clinically defined subgroups remains uncertain. Similarly, although studies have shown an improvement in patients' hemodynamics and quality of life with cardiac resynchronization therapy (CRT), there is a continuing uncertainty about the effect of CRT on patients' survival and the magnitude of improvement in quality of life with this therapy. On August 24, 2004, an ad hoc group of experts representing clinical cardiovascular medicine, biostatistics, economics, and health policy were joined by representatives of the Food and Drug Administration, Centers for Medicare and Medicaid Services (Baltimore, Md), Agency for Healthcare Research and Quality (Rockville, Md), and the device industry for a 1-day round table to review the available clinical trial evidence on the effect of ICD therapy in the primary prevention of sudden cardiac death and the effect of CRT in patients with congestive heart failure. The meeting was organized by the Duke Clinical Research Institute, Durham, NC, and funded in part by the Agency for Healthcare Research and Quality. This document summarizes the evidence reviewed at that meeting and the discussions of that evidence.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

June 2005

Volume

149

Issue

6

Start / End Page

1020 / 1034

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Humans
  • Heart Failure
  • Defibrillators, Implantable
  • Death, Sudden, Cardiac
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
 

Citation

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Al-Khatib, S. M., Sanders, G. D., Mark, D. B., Lee, K. L., Bardy, G. H., Bigger, J. T., … Expert panel participating in a Duke Clinical Research Institute-sponsored conference, . (2005). Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004. Am Heart J, 149(6), 1020–1034. https://doi.org/10.1016/j.ahj.2005.02.005
Al-Khatib, Sana M., Gillian D. Sanders, Daniel B. Mark, Kerry L. Lee, Gust H. Bardy, J Thomas Bigger, Alfred E. Buxton, et al. “Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004.Am Heart J 149, no. 6 (June 2005): 1020–34. https://doi.org/10.1016/j.ahj.2005.02.005.
Al-Khatib SM, Sanders GD, Mark DB, Lee KL, Bardy GH, Bigger JT, et al. Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004. Am Heart J. 2005 Jun;149(6):1020–34.
Al-Khatib, Sana M., et al. “Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004.Am Heart J, vol. 149, no. 6, June 2005, pp. 1020–34. Pubmed, doi:10.1016/j.ahj.2005.02.005.
Al-Khatib SM, Sanders GD, Mark DB, Lee KL, Bardy GH, Bigger JT, Buxton AE, Connolly S, Kadish A, Moss A, Feldman AM, Ellenbogen KA, Singh S, Califf RM, Expert panel participating in a Duke Clinical Research Institute-sponsored conference. Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004. Am Heart J. 2005 Jun;149(6):1020–1034.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

June 2005

Volume

149

Issue

6

Start / End Page

1020 / 1034

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Humans
  • Heart Failure
  • Defibrillators, Implantable
  • Death, Sudden, Cardiac
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services