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Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Publication ,  Journal Article
Al-Khatib, SM; Hellkamp, AS; Lee, KL; Anderson, J; Poole, JE; Mark, DB; Bardy, GH; scd-heft investigators,
Published in: J Cardiovasc Electrophysiol
October 2008

INTRODUCTION: We conducted this study to examine the effect of the ICD on the outcomes of patients with prior coronary revascularization enrolled in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) and to assess the association of time from coronary revascularization to enrollment with death and sudden cardiac death (SCD). METHODS AND RESULTS: We included in this analysis patients with ischemic heart disease not randomized to the amiodarone arm. Cox proportional hazards models were used to examine the association of prior CABG and of prior PCI with each outcome. Interactions between randomized treatment and each revascularization type and time were tested in each model. Of the 882 patients who met these inclusion criteria, 255 (29%) had no prior revascularization, 178 (20%) had prior PCI only, 284 (32%) had prior CABG only, and 165 (19%) had prior PCI and CABG. There was no significant difference in ICD benefit across the revascularization subgroups (all P > 0.1). There was a trend toward improved survival with an ICD in patients who had their CABG > 2 years before randomization (HR [CI] = 0.71 [0.49, 1.04]) that was not observed in patients who had their CABG < or = 2 years before randomization (HR [CI] = 1.40 [0.61, 3.24]). CONCLUSION: In SCD-HeFT, there was no significant difference in ICD benefit across the revascularization subgroups. Patients who had their CABG > 2 years before randomization showed a trend toward improved survival with an ICD that was not observed in patients who had their CABG < or = 2 years before randomization.

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Published In

J Cardiovasc Electrophysiol

DOI

EISSN

1540-8167

Publication Date

October 2008

Volume

19

Issue

10

Start / End Page

1059 / 1065

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Survival Rate
  • Survival Analysis
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Proportional Hazards Models
  • Prognosis
  • Myocardial Revascularization
  • Myocardial Ischemia
 

Citation

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Al-Khatib, S. M., Hellkamp, A. S., Lee, K. L., Anderson, J., Poole, J. E., Mark, D. B., … scd-heft investigators, . (2008). Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). J Cardiovasc Electrophysiol, 19(10), 1059–1065. https://doi.org/10.1111/j.1540-8167.2008.01191.x
Al-Khatib, Sana M., Anne S. Hellkamp, Kerry L. Lee, Jill Anderson, Jeanne E. Poole, Daniel B. Mark, Gust H. Bardy, and Gust H. scd-heft investigators. “Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).J Cardiovasc Electrophysiol 19, no. 10 (October 2008): 1059–65. https://doi.org/10.1111/j.1540-8167.2008.01191.x.
Al-Khatib SM, Hellkamp AS, Lee KL, Anderson J, Poole JE, Mark DB, et al. Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). J Cardiovasc Electrophysiol. 2008 Oct;19(10):1059–65.
Al-Khatib, Sana M., et al. “Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).J Cardiovasc Electrophysiol, vol. 19, no. 10, Oct. 2008, pp. 1059–65. Pubmed, doi:10.1111/j.1540-8167.2008.01191.x.
Al-Khatib SM, Hellkamp AS, Lee KL, Anderson J, Poole JE, Mark DB, Bardy GH, scd-heft investigators. Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). J Cardiovasc Electrophysiol. 2008 Oct;19(10):1059–1065.
Journal cover image

Published In

J Cardiovasc Electrophysiol

DOI

EISSN

1540-8167

Publication Date

October 2008

Volume

19

Issue

10

Start / End Page

1059 / 1065

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Survival Rate
  • Survival Analysis
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Proportional Hazards Models
  • Prognosis
  • Myocardial Revascularization
  • Myocardial Ischemia