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Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I).

Publication ,  Journal Article
Omoigui, NA; Califf, RM; Pieper, K; Keeler, G; O'Hanesian, MA; Berdan, LG; Mark, DB; Talley, JD; Topol, EJ
Published in: J Am Coll Cardiol
October 1995

OBJECTIVES: In-hospital peripheral vascular complications of balloon angioplasty were compared with those of directional atherectomy in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I) to identify patients at risk and evaluate costs and outcomes. BACKGROUND: The incidence, costs and outcomes of peripheral vascular complications after coronary intervention have not been fully characterized as a function of randomly assigned therapy. METHODS: At 35 sites in the United States and Europe, 1,012 patients were randomized. Peripheral vascular complications were defined as the composite of pulse loss, pseudoaneurysm, hematoma > 4 cm in diameter or groin hemorrhage necessitating blood transfusion. Logistic models were derived to 1) predict these complications from baseline and procedural characteristics, 2) test the relevance of randomization assignment, and 3) assess their impact on hospital costs and long-term outcomes. RESULTS: Sixty-seven patients (6.6%) developed peripheral vascular complications, of whom 15 (22.4%) required a blood transfusion, 14 (20.9%) underwent vascular surgery, and 2 (3.0%) died. Both in-hospital deaths occurred in patients with peripheral vascular complications. There was no difference in composite peripheral vascular complication rates among patients randomized to angioplasty or atherectomy. Greater age, female gender, postprocedural heparin and intraaortic balloon counterpulsation were predictive of increased risk. In a representative 60% subset, mean hospital costs increased from $9,583 in patients without to $18,350 in those with peripheral vascular complications (p = 0.0001). The unadjusted mortality rate at 1 year was 7.5% for patients with peripheral vascular complications compared with 1.1% for all others (p = 0.0001). These complications identified patients at greater risk of death, myocardial infarction or repeat revascularization at 30 days and 1 year. The atherectomy group had a trend toward more frequent deaths and myocardial infarction. CONCLUSIONS: Directional atherectomy and balloon angioplasty had similar in-hospital peripheral vascular complication rates. Female gender, greater age, postprocedural heparin and intraaortic balloon counterpulsation were predictive of higher risk. The twofold increase in cost and sevenfold increase in long-term deaths highlight the need to prevent these periprocedural events and monitor patients closely.

Duke Scholars

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

October 1995

Volume

26

Issue

4

Start / End Page

922 / 930

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Risk Factors
  • Prospective Studies
  • Peripheral Vascular Diseases
  • Middle Aged
  • Male
  • Logistic Models
  • Incidence
 

Citation

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ICMJE
MLA
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Omoigui, N. A., Califf, R. M., Pieper, K., Keeler, G., O’Hanesian, M. A., Berdan, L. G., … Topol, E. J. (1995). Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I). J Am Coll Cardiol, 26(4), 922–930. https://doi.org/10.1016/0735-1097(95)00263-4
Omoigui, N. A., R. M. Califf, K. Pieper, G. Keeler, M. A. O’Hanesian, L. G. Berdan, D. B. Mark, J. D. Talley, and E. J. Topol. “Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I).J Am Coll Cardiol 26, no. 4 (October 1995): 922–30. https://doi.org/10.1016/0735-1097(95)00263-4.
Omoigui NA, Califf RM, Pieper K, Keeler G, O’Hanesian MA, Berdan LG, et al. Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I). J Am Coll Cardiol. 1995 Oct;26(4):922–30.
Omoigui, N. A., et al. “Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I).J Am Coll Cardiol, vol. 26, no. 4, Oct. 1995, pp. 922–30. Pubmed, doi:10.1016/0735-1097(95)00263-4.
Omoigui NA, Califf RM, Pieper K, Keeler G, O’Hanesian MA, Berdan LG, Mark DB, Talley JD, Topol EJ. Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I). J Am Coll Cardiol. 1995 Oct;26(4):922–930.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

October 1995

Volume

26

Issue

4

Start / End Page

922 / 930

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Risk Factors
  • Prospective Studies
  • Peripheral Vascular Diseases
  • Middle Aged
  • Male
  • Logistic Models
  • Incidence