Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.
Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.
Duke Scholars
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Related Subject Headings
- Physical Examination
- Neurology & Neurosurgery
- Neuralgia
- Humans
- Chronic Disease
- Analgesics
- 3209 Neurosciences
- 3202 Clinical sciences
- 1702 Cognitive Sciences
- 1109 Neurosciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Physical Examination
- Neurology & Neurosurgery
- Neuralgia
- Humans
- Chronic Disease
- Analgesics
- 3209 Neurosciences
- 3202 Clinical sciences
- 1702 Cognitive Sciences
- 1109 Neurosciences