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Assessment of pain in herpes zoster: lessons learned from antiviral trials.

Publication ,  Journal Article
Dworkin, RH; Carrington, D; Cunningham, A; Kost, RG; Levin, MJ; McKendrick, MW; Oxman, MN; Rentier, B; Schmader, KE; Tappeiner, G; Wassilew, SW ...
Published in: Antiviral Res
January 1997

Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but different methods have been used to analyze pain in recent published trials. These reports are reviewed and their methodological strengths and weaknesses examined. Based on this review, recommendations for the design and analysis of future trials of antiviral agents in herpes zoster are proposed. The principal recommendation is that antiviral efficacy should be evaluated both by distinguishing post-herpetic neuralgia from acute pain and by considering pain as a continuum. The primary endpoint should address both the prevalence and duration of post-herpetic neuralgia and should be examined in those patients who have post-herpetic neuralgia. Adopting the proposed recommendations in design and analysis of future trials should facilitate comparison across trials of the efficacy of antiviral agents in the treatment of herpes zoster.

Duke Scholars

Published In

Antiviral Res

DOI

ISSN

0166-3542

Publication Date

January 1997

Volume

33

Issue

2

Start / End Page

73 / 85

Location

Netherlands

Related Subject Headings

  • Virology
  • Research Design
  • Pain Measurement
  • Humans
  • Herpes Zoster
  • Forecasting
  • Clinical Trials as Topic
  • Antiviral Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology
 

Citation

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Dworkin, R. H., Carrington, D., Cunningham, A., Kost, R. G., Levin, M. J., McKendrick, M. W., … Whitley, R. J. (1997). Assessment of pain in herpes zoster: lessons learned from antiviral trials. Antiviral Res, 33(2), 73–85. https://doi.org/10.1016/s0166-3542(96)01007-8
Dworkin, R. H., D. Carrington, A. Cunningham, R. G. Kost, M. J. Levin, M. W. McKendrick, M. N. Oxman, et al. “Assessment of pain in herpes zoster: lessons learned from antiviral trials.Antiviral Res 33, no. 2 (January 1997): 73–85. https://doi.org/10.1016/s0166-3542(96)01007-8.
Dworkin RH, Carrington D, Cunningham A, Kost RG, Levin MJ, McKendrick MW, et al. Assessment of pain in herpes zoster: lessons learned from antiviral trials. Antiviral Res. 1997 Jan;33(2):73–85.
Dworkin, R. H., et al. “Assessment of pain in herpes zoster: lessons learned from antiviral trials.Antiviral Res, vol. 33, no. 2, Jan. 1997, pp. 73–85. Pubmed, doi:10.1016/s0166-3542(96)01007-8.
Dworkin RH, Carrington D, Cunningham A, Kost RG, Levin MJ, McKendrick MW, Oxman MN, Rentier B, Schmader KE, Tappeiner G, Wassilew SW, Whitley RJ. Assessment of pain in herpes zoster: lessons learned from antiviral trials. Antiviral Res. 1997 Jan;33(2):73–85.
Journal cover image

Published In

Antiviral Res

DOI

ISSN

0166-3542

Publication Date

January 1997

Volume

33

Issue

2

Start / End Page

73 / 85

Location

Netherlands

Related Subject Headings

  • Virology
  • Research Design
  • Pain Measurement
  • Humans
  • Herpes Zoster
  • Forecasting
  • Clinical Trials as Topic
  • Antiviral Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology