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Acute corneal endothelial changes after laser in situ keratomileusis.

Publication ,  Journal Article
Kim, T; Sorenson, AL; Krishnasamy, S; Carlson, AN; Edelhauser, HF
Published in: Cornea
August 2001

PURPOSE: To report the acute effects of laser in situ keratomileusis (LASIK) on the corneal endothelium. METHODS: Twenty eyes of 10 consecutive patients (mean age, 38.1 +/- 10.84 years) underwent bilateral simultaneous LASIK for myopic astigmatism (spherical equivalent ranging from -1.75 to -7.13 diopters) without any complications. Each eye was evaluated by slit-lamp biomicroscopy and noncontact specular microscopy preoperatively, within 15 minutes after LASIK and 1 day after surgery. Specular microscopy images were then analyzed to calculate endothelial cell density (ECD), coefficient of variation (CV) of cell size, and percentage of hexagonal cells. RESULTS: All corneas demonstrated marked alterations in endothelial cell morphology by slit-lamp biomicroscopy within 15 minutes after surgery that resolved by the first postoperative day. Central corneal endothelial analysis by noncontact specular microscopy confirmed pleomorphism with definite loss of hexagonality. Mean ECD was calculated to be 2,816.3 +/- 286.02 cells/mm(2) preoperatively, 2,750.85 +/- 327.95 cells/mm(2) on day 0 (p = 0.395), and 2,810.55 +/- 218.48 cells/mm(2) on day 1 (p = 0.461). Mean CV was 32.65 +/- 7.29 preoperatively, 34.4 +/- 6.19 on day 0 (p = 0.412), and 30.9 +/- 5.54 on day 1 (p = 0.067). Mean percentage of hexagonal cells was 63.35 +/- 10.76 preoperatively, 47.55 +/- 9.69 on day 0 (p = 0.000009), and 60 +/- 9.3 on day 1 (p = 0.00003). CONCLUSION: Qualitative and quantitative changes in endothelial cell morphology (i.e., decreased endothelial cell hexagonality) demonstrate that LASIK does induce an acute effect on the corneal endothelium that may represent transient endothelial cell edema.

Duke Scholars

Published In

Cornea

DOI

ISSN

0277-3740

Publication Date

August 2001

Volume

20

Issue

6

Start / End Page

597 / 602

Location

United States

Related Subject Headings

  • Prospective Studies
  • Postoperative Complications
  • Ophthalmology & Optometry
  • Myopia
  • Middle Aged
  • Male
  • Keratomileusis, Laser In Situ
  • Humans
  • Female
  • Endothelium, Corneal
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kim, T., Sorenson, A. L., Krishnasamy, S., Carlson, A. N., & Edelhauser, H. F. (2001). Acute corneal endothelial changes after laser in situ keratomileusis. Cornea, 20(6), 597–602. https://doi.org/10.1097/00003226-200108000-00008
Kim, T., A. L. Sorenson, S. Krishnasamy, A. N. Carlson, and H. F. Edelhauser. “Acute corneal endothelial changes after laser in situ keratomileusis.Cornea 20, no. 6 (August 2001): 597–602. https://doi.org/10.1097/00003226-200108000-00008.
Kim T, Sorenson AL, Krishnasamy S, Carlson AN, Edelhauser HF. Acute corneal endothelial changes after laser in situ keratomileusis. Cornea. 2001 Aug;20(6):597–602.
Kim, T., et al. “Acute corneal endothelial changes after laser in situ keratomileusis.Cornea, vol. 20, no. 6, Aug. 2001, pp. 597–602. Pubmed, doi:10.1097/00003226-200108000-00008.
Kim T, Sorenson AL, Krishnasamy S, Carlson AN, Edelhauser HF. Acute corneal endothelial changes after laser in situ keratomileusis. Cornea. 2001 Aug;20(6):597–602.

Published In

Cornea

DOI

ISSN

0277-3740

Publication Date

August 2001

Volume

20

Issue

6

Start / End Page

597 / 602

Location

United States

Related Subject Headings

  • Prospective Studies
  • Postoperative Complications
  • Ophthalmology & Optometry
  • Myopia
  • Middle Aged
  • Male
  • Keratomileusis, Laser In Situ
  • Humans
  • Female
  • Endothelium, Corneal