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Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants.

Publication ,  Journal Article
Wathier, M; Johnson, CS; Kim, T; Grinstaff, MW
Published in: Bioconjug Chem
2006

A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.

Duke Scholars

Published In

Bioconjug Chem

DOI

ISSN

1043-1802

Publication Date

2006

Volume

17

Issue

4

Start / End Page

873 / 876

Location

United States

Related Subject Headings

  • Polyethylene Glycols
  • Peptides
  • Organic Chemistry
  • Hydrogels
  • Humans
  • Corneal Transplantation
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0305 Organic Chemistry
 

Citation

APA
Chicago
ICMJE
MLA
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Wathier, M., Johnson, C. S., Kim, T., & Grinstaff, M. W. (2006). Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants. Bioconjug Chem, 17(4), 873–876. https://doi.org/10.1021/bc060060f
Wathier, Michel, C Starck Johnson, Terry Kim, and Mark W. Grinstaff. “Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants.Bioconjug Chem 17, no. 4 (2006): 873–76. https://doi.org/10.1021/bc060060f.
Wathier M, Johnson CS, Kim T, Grinstaff MW. Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants. Bioconjug Chem. 2006;17(4):873–6.
Wathier, Michel, et al. “Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants.Bioconjug Chem, vol. 17, no. 4, 2006, pp. 873–76. Pubmed, doi:10.1021/bc060060f.
Wathier M, Johnson CS, Kim T, Grinstaff MW. Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants. Bioconjug Chem. 2006;17(4):873–876.
Journal cover image

Published In

Bioconjug Chem

DOI

ISSN

1043-1802

Publication Date

2006

Volume

17

Issue

4

Start / End Page

873 / 876

Location

United States

Related Subject Headings

  • Polyethylene Glycols
  • Peptides
  • Organic Chemistry
  • Hydrogels
  • Humans
  • Corneal Transplantation
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0305 Organic Chemistry