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In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive.

Publication ,  Journal Article
Johnson, CS; Wathier, M; Grinstaff, M; Kim, T
Published in: Arch Ophthalmol
April 2009

OBJECTIVE: To determine if a biodendrimer adhesive will seal a clear corneal cataract incision. DESIGN: An experimental study in which 2.75-mm clear corneal cataract incisions were made in 8 human donor eyes. The corneas were mounted on an artificial anterior chamber. Leaking pressure was determined in 6 corneas. These corneas were then treated with adhesive and leaking pressure was again measured in 4 of them. India ink was then applied to the 2 remaining treated and the 2 untreated corneas. Chamber pressure was cycled between 100 and 0 mm Hg. Optical coherence tomography was used to visualize the wound dynamics of a ninth cornea treated with adhesive, mounted, and pressure cycled in a similar fashion. RESULTS: The mean (SD) leaking pressure was 77 (14) mm Hg for the nonsealed wounds and 142 (22) mm Hg for the adhesive-sealed wounds. india ink entered the nonsealed wounds and anterior chamber when the intraocular pressure was cyclically raised and lowered, whereas no india ink entered the adhesive-sealed wounds. The optical coherence tomography-visualized corneal wound did gape under pressure cycling, but the adhesive remained intact and stretched to conform to the wound. CONCLUSIONS: Biodendrimer adhesives may be used to seal cataract wounds to prevent leakage and influx of fluid.

Duke Scholars

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

April 2009

Volume

127

Issue

4

Start / End Page

430 / 434

Location

United States

Related Subject Headings

  • Wound Healing
  • Tomography, Optical Coherence
  • Tissue Adhesives
  • Surgical Wound Dehiscence
  • Ophthalmology & Optometry
  • Minimally Invasive Surgical Procedures
  • Intraocular Pressure
  • Humans
  • Dendrimers
  • Cornea
 

Citation

APA
Chicago
ICMJE
MLA
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Johnson, C. S., Wathier, M., Grinstaff, M., & Kim, T. (2009). In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive. Arch Ophthalmol, 127(4), 430–434. https://doi.org/10.1001/archophthalmol.2009.46
Johnson, C Starck, Michel Wathier, Mark Grinstaff, and Terry Kim. “In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive.Arch Ophthalmol 127, no. 4 (April 2009): 430–34. https://doi.org/10.1001/archophthalmol.2009.46.
Johnson CS, Wathier M, Grinstaff M, Kim T. In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive. Arch Ophthalmol. 2009 Apr;127(4):430–4.
Johnson, C. Starck, et al. “In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive.Arch Ophthalmol, vol. 127, no. 4, Apr. 2009, pp. 430–34. Pubmed, doi:10.1001/archophthalmol.2009.46.
Johnson CS, Wathier M, Grinstaff M, Kim T. In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive. Arch Ophthalmol. 2009 Apr;127(4):430–434.

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

April 2009

Volume

127

Issue

4

Start / End Page

430 / 434

Location

United States

Related Subject Headings

  • Wound Healing
  • Tomography, Optical Coherence
  • Tissue Adhesives
  • Surgical Wound Dehiscence
  • Ophthalmology & Optometry
  • Minimally Invasive Surgical Procedures
  • Intraocular Pressure
  • Humans
  • Dendrimers
  • Cornea